Abstract
Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is applied to provide strong evidence for the chemical reactions of functionalized gold nanoparticles (Au NPs) with analytes - Hg+2 ions induced MPA Au NPs aggregation in the presence of 2,6-pyridinedicarboxylic acid (PDCA) and H2O2 induced fluorescence quenching of 11-MUA Au NDs. PDCA-Hg2+-MPA coordination is responsible for Au NPs aggregation, while the formation of 11-MUA disulfide compounds that release into the bulk solution is responsible for H2O2-induced fluorescence quenching. In addition to providing information about the chemical structures, SALDI-MS is also selective and sensitive for the detection of Hg2+ ions and H2O2. The limits of detection (LODs) for Hg2+ ions and H2O2 by SALDI-MS were 300nM and 250μM, respectively. The spot-to-spot variations in the two studies were both less than 18% (50 sample spots). Our results reveal that SALDI-MS can be used to study analyte-induced changes in the surface properties of nanoparticles.
| Original language | English |
|---|---|
| Pages (from-to) | 933-938 |
| Number of pages | 6 |
| Journal | Rapid Communications in Mass Spectrometry |
| Volume | 24 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2010 Apr 15 |
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All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Spectroscopy
- Organic Chemistry
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Exploring the interactions between gold nanoparticles and analytes through surface-assisted laser desorption/ ionization mass spectrometry. / Lin, Yang-Wei; Chen, Wen Tsen; Chang, Huan Tsung.
In: Rapid Communications in Mass Spectrometry, Vol. 24, No. 7, 15.04.2010, p. 933-938.Research output: Contribution to journal › Article
TY - JOUR
T1 - Exploring the interactions between gold nanoparticles and analytes through surface-assisted laser desorption/ ionization mass spectrometry
AU - Lin, Yang-Wei
AU - Chen, Wen Tsen
AU - Chang, Huan Tsung
PY - 2010/4/15
Y1 - 2010/4/15
N2 - Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is applied to provide strong evidence for the chemical reactions of functionalized gold nanoparticles (Au NPs) with analytes - Hg+2 ions induced MPA Au NPs aggregation in the presence of 2,6-pyridinedicarboxylic acid (PDCA) and H2O2 induced fluorescence quenching of 11-MUA Au NDs. PDCA-Hg2+-MPA coordination is responsible for Au NPs aggregation, while the formation of 11-MUA disulfide compounds that release into the bulk solution is responsible for H2O2-induced fluorescence quenching. In addition to providing information about the chemical structures, SALDI-MS is also selective and sensitive for the detection of Hg2+ ions and H2O2. The limits of detection (LODs) for Hg2+ ions and H2O2 by SALDI-MS were 300nM and 250μM, respectively. The spot-to-spot variations in the two studies were both less than 18% (50 sample spots). Our results reveal that SALDI-MS can be used to study analyte-induced changes in the surface properties of nanoparticles.
AB - Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is applied to provide strong evidence for the chemical reactions of functionalized gold nanoparticles (Au NPs) with analytes - Hg+2 ions induced MPA Au NPs aggregation in the presence of 2,6-pyridinedicarboxylic acid (PDCA) and H2O2 induced fluorescence quenching of 11-MUA Au NDs. PDCA-Hg2+-MPA coordination is responsible for Au NPs aggregation, while the formation of 11-MUA disulfide compounds that release into the bulk solution is responsible for H2O2-induced fluorescence quenching. In addition to providing information about the chemical structures, SALDI-MS is also selective and sensitive for the detection of Hg2+ ions and H2O2. The limits of detection (LODs) for Hg2+ ions and H2O2 by SALDI-MS were 300nM and 250μM, respectively. The spot-to-spot variations in the two studies were both less than 18% (50 sample spots). Our results reveal that SALDI-MS can be used to study analyte-induced changes in the surface properties of nanoparticles.
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U2 - 10.1002/rcm.4473
DO - 10.1002/rcm.4473
M3 - Article
VL - 24
SP - 933
EP - 938
JO - Rapid Communications in Mass Spectrometry
JF - Rapid Communications in Mass Spectrometry
SN - 0951-4198
IS - 7
ER -