Exploring the interactions between gold nanoparticles and analytes through surface-assisted laser desorption/ ionization mass spectrometry

Yang Wei Lin, Wen Tsen Chen, Huan Tsung Chang

Research output: Contribution to journalArticle

19 Citations (Scopus)


Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is applied to provide strong evidence for the chemical reactions of functionalized gold nanoparticles (Au NPs) with analytes - Hg+2 ions induced MPA Au NPs aggregation in the presence of 2,6-pyridinedicarboxylic acid (PDCA) and H2O2 induced fluorescence quenching of 11-MUA Au NDs. PDCA-Hg2+-MPA coordination is responsible for Au NPs aggregation, while the formation of 11-MUA disulfide compounds that release into the bulk solution is responsible for H2O2-induced fluorescence quenching. In addition to providing information about the chemical structures, SALDI-MS is also selective and sensitive for the detection of Hg2+ ions and H2O2. The limits of detection (LODs) for Hg2+ ions and H2O2 by SALDI-MS were 300nM and 250μM, respectively. The spot-to-spot variations in the two studies were both less than 18% (50 sample spots). Our results reveal that SALDI-MS can be used to study analyte-induced changes in the surface properties of nanoparticles.

Original languageEnglish
Pages (from-to)933-938
Number of pages6
JournalRapid Communications in Mass Spectrometry
Issue number7
Publication statusPublished - 2010 Apr 15


All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry

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