Exploring the interactions between gold nanoparticles and analytes through surface-assisted laser desorption/ ionization mass spectrometry

Yang Wei Lin; Wen Tsen Chen; Huan Tsung Chang

doi:10.1002/rcm.4473

Exploring the interactions between gold nanoparticles and analytes through surface-assisted laser desorption/ ionization mass spectrometry

Yang Wei Lin, Wen Tsen Chen, Huan Tsung Chang

Department of Chemistry

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19 Citations (Scopus)

Abstract

Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is applied to provide strong evidence for the chemical reactions of functionalized gold nanoparticles (Au NPs) with analytes - Hg⁺² ions induced MPA Au NPs aggregation in the presence of 2,6-pyridinedicarboxylic acid (PDCA) and H₂O₂ induced fluorescence quenching of 11-MUA Au NDs. PDCA-Hg²⁺-MPA coordination is responsible for Au NPs aggregation, while the formation of 11-MUA disulfide compounds that release into the bulk solution is responsible for H₂O₂-induced fluorescence quenching. In addition to providing information about the chemical structures, SALDI-MS is also selective and sensitive for the detection of Hg²⁺ ions and H₂O₂. The limits of detection (LODs) for Hg²⁺ ions and H₂O₂ by SALDI-MS were 300nM and 250μM, respectively. The spot-to-spot variations in the two studies were both less than 18% (50 sample spots). Our results reveal that SALDI-MS can be used to study analyte-induced changes in the surface properties of nanoparticles.

Original language	English
Pages (from-to)	933-938
Number of pages	6
Journal	Rapid Communications in Mass Spectrometry
Volume	24
Issue number	7
DOIs	https://doi.org/10.1002/rcm.4473
Publication status	Published - 2010 Apr 15

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Spectroscopy
Organic Chemistry

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title = "Exploring the interactions between gold nanoparticles and analytes through surface-assisted laser desorption/ ionization mass spectrometry",

abstract = "Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is applied to provide strong evidence for the chemical reactions of functionalized gold nanoparticles (Au NPs) with analytes - Hg+2 ions induced MPA Au NPs aggregation in the presence of 2,6-pyridinedicarboxylic acid (PDCA) and H2O2 induced fluorescence quenching of 11-MUA Au NDs. PDCA-Hg2+-MPA coordination is responsible for Au NPs aggregation, while the formation of 11-MUA disulfide compounds that release into the bulk solution is responsible for H2O2-induced fluorescence quenching. In addition to providing information about the chemical structures, SALDI-MS is also selective and sensitive for the detection of Hg2+ ions and H2O2. The limits of detection (LODs) for Hg2+ ions and H2O2 by SALDI-MS were 300nM and 250μM, respectively. The spot-to-spot variations in the two studies were both less than 18% (50 sample spots). Our results reveal that SALDI-MS can be used to study analyte-induced changes in the surface properties of nanoparticles.",

author = "Lin, {Yang Wei} and Chen, {Wen Tsen} and Chang, {Huan Tsung}",

year = "2010",

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AU - Lin, Yang Wei

AU - Chen, Wen Tsen

AU - Chang, Huan Tsung

PY - 2010/4/15

Y1 - 2010/4/15

N2 - Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is applied to provide strong evidence for the chemical reactions of functionalized gold nanoparticles (Au NPs) with analytes - Hg+2 ions induced MPA Au NPs aggregation in the presence of 2,6-pyridinedicarboxylic acid (PDCA) and H2O2 induced fluorescence quenching of 11-MUA Au NDs. PDCA-Hg2+-MPA coordination is responsible for Au NPs aggregation, while the formation of 11-MUA disulfide compounds that release into the bulk solution is responsible for H2O2-induced fluorescence quenching. In addition to providing information about the chemical structures, SALDI-MS is also selective and sensitive for the detection of Hg2+ ions and H2O2. The limits of detection (LODs) for Hg2+ ions and H2O2 by SALDI-MS were 300nM and 250μM, respectively. The spot-to-spot variations in the two studies were both less than 18% (50 sample spots). Our results reveal that SALDI-MS can be used to study analyte-induced changes in the surface properties of nanoparticles.

AB - Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is applied to provide strong evidence for the chemical reactions of functionalized gold nanoparticles (Au NPs) with analytes - Hg+2 ions induced MPA Au NPs aggregation in the presence of 2,6-pyridinedicarboxylic acid (PDCA) and H2O2 induced fluorescence quenching of 11-MUA Au NDs. PDCA-Hg2+-MPA coordination is responsible for Au NPs aggregation, while the formation of 11-MUA disulfide compounds that release into the bulk solution is responsible for H2O2-induced fluorescence quenching. In addition to providing information about the chemical structures, SALDI-MS is also selective and sensitive for the detection of Hg2+ ions and H2O2. The limits of detection (LODs) for Hg2+ ions and H2O2 by SALDI-MS were 300nM and 250μM, respectively. The spot-to-spot variations in the two studies were both less than 18% (50 sample spots). Our results reveal that SALDI-MS can be used to study analyte-induced changes in the surface properties of nanoparticles.

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