Epigenetic stratification: The role of individual change in the biological aging process

S. Michal Jazwinski, Sangkyu Kim, Chi Yung Lai, Alberto Benguria

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Aging is a complex process. It consists of a diverse assortment of seemingly random manifestations that occur in the individual, the mutual relationship and impact on mortality of which is frequently obscure. We derive a simple equation to model the aging process based on scale invariant and increasing change. The solution to this equation indicates that this change itself, irrespective of its quality, is the cause and not simply the effect of aging. This model establishes loss of homeostasis as a fundamental feature of aging. The model is deterministic, but it supports the stochastic nature of age changes. Paradoxically, this model states that a sufficient augmentation of aging processes results in a lack of aging. Experimental evidence in support of this model is presented that spans the levels of population mortality rates, cellular spatial organization, and gene dysregulation.

Original languageEnglish
Pages (from-to)571-580
Number of pages10
JournalExperimental Gerontology
Volume33
Issue number6
DOIs
Publication statusPublished - 1998 Sep

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Ageing
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

Cite this