End-to-end thiocyanato-bridged zig-zag polymers of Cu II, Co II and Ni II with a hydrazone ligand: EPR, magnetic susceptibility and biological study

Amitabha Datta, Pei Hsin Liu, Jui Hsien Huang, Eugenio Garribba, Mark Turnbull, Barbara MacHura, Chin Lin Hsu, Wei Tang Chang, Andrej Pevec

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The reactions of a tridentate hydrazone ligand, N′-[1-(pyridin-2-yl) ethylidene]acetohydrazide (LH), derived from condensation of 2-acetylpyridine with acetic hydrazide, with M(NO 3) 2·nH 2O [M = Cu, Co and Ni] in the presence of thiocyanate afford three end-to-end zig-zag coordination polymers, [CuLH(NO 3)(μ 1,3-NCS)] n·nH 2O (1), [CoLH(NCS)(μ 1,3-NCS)] n (2) and [NiLH(NCS)(μ 1,3-NCS)] n (3) (where LH = CH 3C(O)-N-NCCH 3C 5H 4N). Single-crystal X-ray structural determination studies reveal that in all the complexes, the hydrazone ligand in the neutral keto form (LH) coordinates a M II ion that is bridged to two neighboring metal centers by SCN - anions, generating a 1-D helical coordination chain. In 1, the Cu II atom adopts a distorted tetragonal bipyramid geometry whereas in 2 and 3, the central Co II or Ni II atom possesses into a distorted octahedral environment. All the aforementioned compounds have been fully characterized by elemental analysis, IR, UV-Vis and EPR spectra. Variable temperature magnetic susceptibility measurement of 1 accounts the weak antiferromagnetic interactions whereas 2 shows single-ion anisotropy. Compound 3 is well described as a 3-D ferromagnetic. The inhibitory effects of all the complexes on the cell population growth of human lung carcinoma cells (A549 cells), human colorectal carcinoma cells (COLO 205 cells and HT-29 cells), and human hepatocellular carcinoma cells (PLC5 cells) were determined by MTT assays.

Original languageEnglish
Pages (from-to)77-87
Number of pages11
JournalPolyhedron
Volume44
Issue number1
DOIs
Publication statusPublished - 2012 Aug 31

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Hydrazones
hydrazones
Magnetic susceptibility
Paramagnetic resonance
Polymers
Ligands
Cells
magnetic permeability
ligands
cancer
polymers
cells
Ions
hydrazides
Atoms
coordination polymers
Acetic Acid
lungs
Anions
atoms

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Datta, Amitabha ; Liu, Pei Hsin ; Huang, Jui Hsien ; Garribba, Eugenio ; Turnbull, Mark ; MacHura, Barbara ; Hsu, Chin Lin ; Chang, Wei Tang ; Pevec, Andrej. / End-to-end thiocyanato-bridged zig-zag polymers of Cu II, Co II and Ni II with a hydrazone ligand : EPR, magnetic susceptibility and biological study. In: Polyhedron. 2012 ; Vol. 44, No. 1. pp. 77-87.
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abstract = "The reactions of a tridentate hydrazone ligand, N′-[1-(pyridin-2-yl) ethylidene]acetohydrazide (LH), derived from condensation of 2-acetylpyridine with acetic hydrazide, with M(NO 3) 2·nH 2O [M = Cu, Co and Ni] in the presence of thiocyanate afford three end-to-end zig-zag coordination polymers, [CuLH(NO 3)(μ 1,3-NCS)] n·nH 2O (1), [CoLH(NCS)(μ 1,3-NCS)] n (2) and [NiLH(NCS)(μ 1,3-NCS)] n (3) (where LH = CH 3C(O)-N-NCCH 3C 5H 4N). Single-crystal X-ray structural determination studies reveal that in all the complexes, the hydrazone ligand in the neutral keto form (LH) coordinates a M II ion that is bridged to two neighboring metal centers by SCN - anions, generating a 1-D helical coordination chain. In 1, the Cu II atom adopts a distorted tetragonal bipyramid geometry whereas in 2 and 3, the central Co II or Ni II atom possesses into a distorted octahedral environment. All the aforementioned compounds have been fully characterized by elemental analysis, IR, UV-Vis and EPR spectra. Variable temperature magnetic susceptibility measurement of 1 accounts the weak antiferromagnetic interactions whereas 2 shows single-ion anisotropy. Compound 3 is well described as a 3-D ferromagnetic. The inhibitory effects of all the complexes on the cell population growth of human lung carcinoma cells (A549 cells), human colorectal carcinoma cells (COLO 205 cells and HT-29 cells), and human hepatocellular carcinoma cells (PLC5 cells) were determined by MTT assays.",
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End-to-end thiocyanato-bridged zig-zag polymers of Cu II, Co II and Ni II with a hydrazone ligand : EPR, magnetic susceptibility and biological study. / Datta, Amitabha; Liu, Pei Hsin; Huang, Jui Hsien; Garribba, Eugenio; Turnbull, Mark; MacHura, Barbara; Hsu, Chin Lin; Chang, Wei Tang; Pevec, Andrej.

In: Polyhedron, Vol. 44, No. 1, 31.08.2012, p. 77-87.

Research output: Contribution to journalArticle

TY - JOUR

T1 - End-to-end thiocyanato-bridged zig-zag polymers of Cu II, Co II and Ni II with a hydrazone ligand

T2 - EPR, magnetic susceptibility and biological study

AU - Datta, Amitabha

AU - Liu, Pei Hsin

AU - Huang, Jui Hsien

AU - Garribba, Eugenio

AU - Turnbull, Mark

AU - MacHura, Barbara

AU - Hsu, Chin Lin

AU - Chang, Wei Tang

AU - Pevec, Andrej

PY - 2012/8/31

Y1 - 2012/8/31

N2 - The reactions of a tridentate hydrazone ligand, N′-[1-(pyridin-2-yl) ethylidene]acetohydrazide (LH), derived from condensation of 2-acetylpyridine with acetic hydrazide, with M(NO 3) 2·nH 2O [M = Cu, Co and Ni] in the presence of thiocyanate afford three end-to-end zig-zag coordination polymers, [CuLH(NO 3)(μ 1,3-NCS)] n·nH 2O (1), [CoLH(NCS)(μ 1,3-NCS)] n (2) and [NiLH(NCS)(μ 1,3-NCS)] n (3) (where LH = CH 3C(O)-N-NCCH 3C 5H 4N). Single-crystal X-ray structural determination studies reveal that in all the complexes, the hydrazone ligand in the neutral keto form (LH) coordinates a M II ion that is bridged to two neighboring metal centers by SCN - anions, generating a 1-D helical coordination chain. In 1, the Cu II atom adopts a distorted tetragonal bipyramid geometry whereas in 2 and 3, the central Co II or Ni II atom possesses into a distorted octahedral environment. All the aforementioned compounds have been fully characterized by elemental analysis, IR, UV-Vis and EPR spectra. Variable temperature magnetic susceptibility measurement of 1 accounts the weak antiferromagnetic interactions whereas 2 shows single-ion anisotropy. Compound 3 is well described as a 3-D ferromagnetic. The inhibitory effects of all the complexes on the cell population growth of human lung carcinoma cells (A549 cells), human colorectal carcinoma cells (COLO 205 cells and HT-29 cells), and human hepatocellular carcinoma cells (PLC5 cells) were determined by MTT assays.

AB - The reactions of a tridentate hydrazone ligand, N′-[1-(pyridin-2-yl) ethylidene]acetohydrazide (LH), derived from condensation of 2-acetylpyridine with acetic hydrazide, with M(NO 3) 2·nH 2O [M = Cu, Co and Ni] in the presence of thiocyanate afford three end-to-end zig-zag coordination polymers, [CuLH(NO 3)(μ 1,3-NCS)] n·nH 2O (1), [CoLH(NCS)(μ 1,3-NCS)] n (2) and [NiLH(NCS)(μ 1,3-NCS)] n (3) (where LH = CH 3C(O)-N-NCCH 3C 5H 4N). Single-crystal X-ray structural determination studies reveal that in all the complexes, the hydrazone ligand in the neutral keto form (LH) coordinates a M II ion that is bridged to two neighboring metal centers by SCN - anions, generating a 1-D helical coordination chain. In 1, the Cu II atom adopts a distorted tetragonal bipyramid geometry whereas in 2 and 3, the central Co II or Ni II atom possesses into a distorted octahedral environment. All the aforementioned compounds have been fully characterized by elemental analysis, IR, UV-Vis and EPR spectra. Variable temperature magnetic susceptibility measurement of 1 accounts the weak antiferromagnetic interactions whereas 2 shows single-ion anisotropy. Compound 3 is well described as a 3-D ferromagnetic. The inhibitory effects of all the complexes on the cell population growth of human lung carcinoma cells (A549 cells), human colorectal carcinoma cells (COLO 205 cells and HT-29 cells), and human hepatocellular carcinoma cells (PLC5 cells) were determined by MTT assays.

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