End-to-end thiocyanato-bridged zig-zag polymers of Cu II, Co II and Ni II with a hydrazone ligand: EPR, magnetic susceptibility and biological study

Amitabha Datta, Pei Hsin Liu, Jui Hsien Huang, Eugenio Garribba, Mark Turnbull, Barbara MacHura, Chin Lin Hsu, Wei Tang Chang, Andrej Pevec

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Abstract

The reactions of a tridentate hydrazone ligand, N′-[1-(pyridin-2-yl) ethylidene]acetohydrazide (LH), derived from condensation of 2-acetylpyridine with acetic hydrazide, with M(NO 3) 2·nH 2O [M = Cu, Co and Ni] in the presence of thiocyanate afford three end-to-end zig-zag coordination polymers, [CuLH(NO 3)(μ 1,3-NCS)] n·nH 2O (1), [CoLH(NCS)(μ 1,3-NCS)] n (2) and [NiLH(NCS)(μ 1,3-NCS)] n (3) (where LH = CH 3C(O)-N-NCCH 3C 5H 4N). Single-crystal X-ray structural determination studies reveal that in all the complexes, the hydrazone ligand in the neutral keto form (LH) coordinates a M II ion that is bridged to two neighboring metal centers by SCN - anions, generating a 1-D helical coordination chain. In 1, the Cu II atom adopts a distorted tetragonal bipyramid geometry whereas in 2 and 3, the central Co II or Ni II atom possesses into a distorted octahedral environment. All the aforementioned compounds have been fully characterized by elemental analysis, IR, UV-Vis and EPR spectra. Variable temperature magnetic susceptibility measurement of 1 accounts the weak antiferromagnetic interactions whereas 2 shows single-ion anisotropy. Compound 3 is well described as a 3-D ferromagnetic. The inhibitory effects of all the complexes on the cell population growth of human lung carcinoma cells (A549 cells), human colorectal carcinoma cells (COLO 205 cells and HT-29 cells), and human hepatocellular carcinoma cells (PLC5 cells) were determined by MTT assays.

Original languageEnglish
Pages (from-to)77-87
Number of pages11
JournalPolyhedron
Volume44
Issue number1
DOIs
Publication statusPublished - 2012 Aug 31

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All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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