Abstract
The reactions of the tridentate hydrazone ligand, N'-[1-(pyridin- 2-yl)ethylidene]acetohydrazide (HL), obtained by condensation of 2-acetylpyridine with acetic hyadrazide, with copper nitrate trihydrate in the presence of thiocyanate, or with CuCl2 produce two distinct coordination compounds, namely a one-dimensional helical coordination chain of [CuL(NCS)]n (1) units, and a doubly chlorido-bridged dinuclear complex [Cu2L2Cl2] (2) (where L=CH 3C(O)=N-N=CCH3C5H4N). Single-crystal X-ray structural determination studies reveal that in complex 1, a deprotonated hydrazone ligand L- coordinates a copper(II) ion that is bridged to two neighbouring metal centres by SCN- anions, generating a one-dimensional helical coordination chain. In complex 2, two symmetry-related, adjacent copper(II) coordination entities are doubly chlorido-bridged, producing a dicopper entity with a Cu···Cu distance of 3.402 (1) Å. The two coordination compounds have been fully characterised by elemental analysis, spectroscopic techniques including IR, UV- vis and electron paramagnetic resonance, and variable-temperature magnetic studies. The biological effects of 1 and 2 on the viability of human colorectal carcinoma cells (COLO-205 and HT-29) were evaluated using an MTT assay, and the results indicate that these complexes induce a decrease in cell-population growth of human colorectal carcinoma cells with apoptosis.
| Original language | English |
|---|---|
| Pages (from-to) | 80-89 |
| Number of pages | 10 |
| Journal | ChemistryOpen |
| Volume | 1 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2012 Apr |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
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End-to-end thiocyanato-bridged helical chain polymer and dichlorido-bridged copper(II) complexes with a hydrazone ligand : Synthesis, characterisation by electron paramagnetic resonance and variable-temperature magnetic studies, and inhibitory effects on human colorectal carcinoma cells. / Das, Kuheli; Datta, Amitabha; Sinha, Chittaranjan; Huang, Jui Hsien; Garribba, Eugenio; Hsiao, Ching Sheng; Hsu, Chin Lin.
In: ChemistryOpen, Vol. 1, No. 2, 04.2012, p. 80-89.Research output: Contribution to journal › Article
TY - JOUR
T1 - End-to-end thiocyanato-bridged helical chain polymer and dichlorido-bridged copper(II) complexes with a hydrazone ligand
T2 - Synthesis, characterisation by electron paramagnetic resonance and variable-temperature magnetic studies, and inhibitory effects on human colorectal carcinoma cells
AU - Das, Kuheli
AU - Datta, Amitabha
AU - Sinha, Chittaranjan
AU - Huang, Jui Hsien
AU - Garribba, Eugenio
AU - Hsiao, Ching Sheng
AU - Hsu, Chin Lin
PY - 2012/4
Y1 - 2012/4
N2 - The reactions of the tridentate hydrazone ligand, N'-[1-(pyridin- 2-yl)ethylidene]acetohydrazide (HL), obtained by condensation of 2-acetylpyridine with acetic hyadrazide, with copper nitrate trihydrate in the presence of thiocyanate, or with CuCl2 produce two distinct coordination compounds, namely a one-dimensional helical coordination chain of [CuL(NCS)]n (1) units, and a doubly chlorido-bridged dinuclear complex [Cu2L2Cl2] (2) (where L=CH 3C(O)=N-N=CCH3C5H4N). Single-crystal X-ray structural determination studies reveal that in complex 1, a deprotonated hydrazone ligand L- coordinates a copper(II) ion that is bridged to two neighbouring metal centres by SCN- anions, generating a one-dimensional helical coordination chain. In complex 2, two symmetry-related, adjacent copper(II) coordination entities are doubly chlorido-bridged, producing a dicopper entity with a Cu···Cu distance of 3.402 (1) Å. The two coordination compounds have been fully characterised by elemental analysis, spectroscopic techniques including IR, UV- vis and electron paramagnetic resonance, and variable-temperature magnetic studies. The biological effects of 1 and 2 on the viability of human colorectal carcinoma cells (COLO-205 and HT-29) were evaluated using an MTT assay, and the results indicate that these complexes induce a decrease in cell-population growth of human colorectal carcinoma cells with apoptosis.
AB - The reactions of the tridentate hydrazone ligand, N'-[1-(pyridin- 2-yl)ethylidene]acetohydrazide (HL), obtained by condensation of 2-acetylpyridine with acetic hyadrazide, with copper nitrate trihydrate in the presence of thiocyanate, or with CuCl2 produce two distinct coordination compounds, namely a one-dimensional helical coordination chain of [CuL(NCS)]n (1) units, and a doubly chlorido-bridged dinuclear complex [Cu2L2Cl2] (2) (where L=CH 3C(O)=N-N=CCH3C5H4N). Single-crystal X-ray structural determination studies reveal that in complex 1, a deprotonated hydrazone ligand L- coordinates a copper(II) ion that is bridged to two neighbouring metal centres by SCN- anions, generating a one-dimensional helical coordination chain. In complex 2, two symmetry-related, adjacent copper(II) coordination entities are doubly chlorido-bridged, producing a dicopper entity with a Cu···Cu distance of 3.402 (1) Å. The two coordination compounds have been fully characterised by elemental analysis, spectroscopic techniques including IR, UV- vis and electron paramagnetic resonance, and variable-temperature magnetic studies. The biological effects of 1 and 2 on the viability of human colorectal carcinoma cells (COLO-205 and HT-29) were evaluated using an MTT assay, and the results indicate that these complexes induce a decrease in cell-population growth of human colorectal carcinoma cells with apoptosis.
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U2 - 10.1002/open.201100011
DO - 10.1002/open.201100011
M3 - Article
AN - SCOPUS:84994417808
VL - 1
SP - 80
EP - 89
JO - ChemistryOpen
JF - ChemistryOpen
SN - 2191-1363
IS - 2
ER -