End-to-end thiocyanato-bridged helical chain polymer and dichlorido-bridged copper(II) complexes with a hydrazone ligand: Synthesis, characterisation by electron paramagnetic resonance and variable-temperature magnetic studies, and inhibitory effects on human colorectal carcinoma cells

Kuheli Das, Amitabha Datta, Chittaranjan Sinha, Jui Hsien Huang, Eugenio Garribba, Ching Sheng Hsiao, Chin Lin Hsu

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16 Citations (Scopus)

Abstract

The reactions of the tridentate hydrazone ligand, N'-[1-(pyridin- 2-yl)ethylidene]acetohydrazide (HL), obtained by condensation of 2-acetylpyridine with acetic hyadrazide, with copper nitrate trihydrate in the presence of thiocyanate, or with CuCl2 produce two distinct coordination compounds, namely a one-dimensional helical coordination chain of [CuL(NCS)]n (1) units, and a doubly chlorido-bridged dinuclear complex [Cu2L2Cl2] (2) (where L=CH 3C(O)=N-N=CCH3C5H4N). Single-crystal X-ray structural determination studies reveal that in complex 1, a deprotonated hydrazone ligand L- coordinates a copper(II) ion that is bridged to two neighbouring metal centres by SCN- anions, generating a one-dimensional helical coordination chain. In complex 2, two symmetry-related, adjacent copper(II) coordination entities are doubly chlorido-bridged, producing a dicopper entity with a Cu···Cu distance of 3.402 (1) Å. The two coordination compounds have been fully characterised by elemental analysis, spectroscopic techniques including IR, UV- vis and electron paramagnetic resonance, and variable-temperature magnetic studies. The biological effects of 1 and 2 on the viability of human colorectal carcinoma cells (COLO-205 and HT-29) were evaluated using an MTT assay, and the results indicate that these complexes induce a decrease in cell-population growth of human colorectal carcinoma cells with apoptosis.

Original languageEnglish
Pages (from-to)80-89
Number of pages10
JournalChemistryOpen
Volume1
Issue number2
DOIs
Publication statusPublished - 2012 Apr

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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