End stage renal disease as a potential risk factor for retinal vein occlusion

San Ni Chen, Te Cheng Yang, Jian Teng Lin, Ie Bin Lian

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

End stage renal disease (ESRD) has been reported to be an important risk factor for systemic vascular disease. Retinal vein occlusion (RVO) is closely related with cardiovascular diseases; however, its association with ESRD had not been reported. The aim of the study was to investigate whether ESRD is a risk factor for RVO, including central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO). This population-based study is based on the longitudinal data from Taiwan National Health Insurance Research Database. The study cohort comprised 5344 patients with diagnosis of ESRD on hemodialysis or peritoneal dialysis during the period from January 1996 to December 2011. For each ESRD patient, we selected 20 non-ESRD patients matched on age and sex. Each ESRD patient and his/her controls were followed from the initiation of renal dialysis until either the diagnosis of RVO or censorship. Kaplan-Meier method was used to compare the hazard of RVO between cohorts. Stratified Cox proportional hazard models were applied to estimate the hazard ratio (HR) adjusted by the comorbidities of RVO including diabetes mellitus (DM), hypertension, hypercholesteremia, and hypertriglyceridemia. After stratifying by DM status, the statistics were applied again to examine the associations among the DM cohort and non-DM cohort. The 16-year RVO cumulative incidence for ESRD cohort was 2-fold to the non-ESRD (1.01% vs 0.46%). After matching with age, sex, hypertension, and hypercholesteremia, the adjusted HR was 1.46 (95% confidence interval=1.07-2.01, P value=0.018). By further excluding patients with DM, the adjusted HR escalated to 2.43 (95% confi-dence interval=1.54-3.83, P<0.001). In contrast, there was no significant risk of ESRD on RVO in the DM patients (HR=1.03). We conclude that among the non-DM patients, ESRD cases had significantly higher RVO rate than the non-ESRD, which indicates that ESRD maybe a potential risk factor for the development of RVO in nondiabetic patients.

Original languageEnglish
Pages (from-to)e1960
JournalMedicine (United States)
Volume94
Issue number47
DOIs
Publication statusPublished - 2015 Nov

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Retinal Vein Occlusion
Chronic Kidney Failure
Diabetes Mellitus
Hypercholesterolemia
Kidney
Renal Dialysis
Hypertension
Retinal Vein
Hypertriglyceridemia
National Health Programs
Peritoneal Dialysis
Taiwan
Vascular Diseases
Proportional Hazards Models
Comorbidity
Cohort Studies
Cardiovascular Diseases
Databases
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chen, San Ni ; Yang, Te Cheng ; Lin, Jian Teng ; Lian, Ie Bin. / End stage renal disease as a potential risk factor for retinal vein occlusion. In: Medicine (United States). 2015 ; Vol. 94, No. 47. pp. e1960.
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title = "End stage renal disease as a potential risk factor for retinal vein occlusion",
abstract = "End stage renal disease (ESRD) has been reported to be an important risk factor for systemic vascular disease. Retinal vein occlusion (RVO) is closely related with cardiovascular diseases; however, its association with ESRD had not been reported. The aim of the study was to investigate whether ESRD is a risk factor for RVO, including central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO). This population-based study is based on the longitudinal data from Taiwan National Health Insurance Research Database. The study cohort comprised 5344 patients with diagnosis of ESRD on hemodialysis or peritoneal dialysis during the period from January 1996 to December 2011. For each ESRD patient, we selected 20 non-ESRD patients matched on age and sex. Each ESRD patient and his/her controls were followed from the initiation of renal dialysis until either the diagnosis of RVO or censorship. Kaplan-Meier method was used to compare the hazard of RVO between cohorts. Stratified Cox proportional hazard models were applied to estimate the hazard ratio (HR) adjusted by the comorbidities of RVO including diabetes mellitus (DM), hypertension, hypercholesteremia, and hypertriglyceridemia. After stratifying by DM status, the statistics were applied again to examine the associations among the DM cohort and non-DM cohort. The 16-year RVO cumulative incidence for ESRD cohort was 2-fold to the non-ESRD (1.01{\%} vs 0.46{\%}). After matching with age, sex, hypertension, and hypercholesteremia, the adjusted HR was 1.46 (95{\%} confidence interval=1.07-2.01, P value=0.018). By further excluding patients with DM, the adjusted HR escalated to 2.43 (95{\%} confi-dence interval=1.54-3.83, P<0.001). In contrast, there was no significant risk of ESRD on RVO in the DM patients (HR=1.03). We conclude that among the non-DM patients, ESRD cases had significantly higher RVO rate than the non-ESRD, which indicates that ESRD maybe a potential risk factor for the development of RVO in nondiabetic patients.",
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End stage renal disease as a potential risk factor for retinal vein occlusion. / Chen, San Ni; Yang, Te Cheng; Lin, Jian Teng; Lian, Ie Bin.

In: Medicine (United States), Vol. 94, No. 47, 11.2015, p. e1960.

Research output: Contribution to journalArticle

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