Effects of KRAS mutation and polymorphism on the risk and prognosis of oral squamous cell carcinoma

Wen Yi Wang, Yi-Chih Chien, Yong Kie Wong, Yan Liang Lin, Jin Ching Lin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background Mutations or single nucleotide polymorphism (SNP) of relevant genes may affect the risk and prognosis of malignancies. The purpose of this study was to analyze whether the KRAS polymorphisms and mutations can be useful prognostic or risk markers in oral squamous cell carcinoma (OSCC). Methods DNA was extracted from tumor tissues of 47 patients with OSCC and blood cells of 84 normal controls and subjected to sequencing for the KRAS. Results No mutation in the KRAS was found in 47 OSCC samples. However, 2 polymorphisms (rs1137282 and rs712) were detected. Individuals with KRAS SNP rs712 genotypes of G/T or T/T have a reduced risk for OSCC than those with genotype G/G (hazard ratio [HR], 0.26; 95% confidence interval [CI], 0.10-0.60; p =.004). The overall survival between different SNPs were not statistically significant (p =.147 for rs1137282 and p =.202 for rs712). Conclusion These data demonstrate a role for rs712 polymorphism of the KRAS in susceptibility of OSCC.

Original languageEnglish
Pages (from-to)663-666
Number of pages4
JournalHead and Neck
Volume34
Issue number5
DOIs
Publication statusPublished - 2012 May 1

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Squamous Cell Carcinoma
Mutation
Single Nucleotide Polymorphism
Genotype
Blood Cells
Neoplasms
Confidence Intervals
Survival
DNA
Genes

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Wang, Wen Yi ; Chien, Yi-Chih ; Wong, Yong Kie ; Lin, Yan Liang ; Lin, Jin Ching. / Effects of KRAS mutation and polymorphism on the risk and prognosis of oral squamous cell carcinoma. In: Head and Neck. 2012 ; Vol. 34, No. 5. pp. 663-666.
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abstract = "Background Mutations or single nucleotide polymorphism (SNP) of relevant genes may affect the risk and prognosis of malignancies. The purpose of this study was to analyze whether the KRAS polymorphisms and mutations can be useful prognostic or risk markers in oral squamous cell carcinoma (OSCC). Methods DNA was extracted from tumor tissues of 47 patients with OSCC and blood cells of 84 normal controls and subjected to sequencing for the KRAS. Results No mutation in the KRAS was found in 47 OSCC samples. However, 2 polymorphisms (rs1137282 and rs712) were detected. Individuals with KRAS SNP rs712 genotypes of G/T or T/T have a reduced risk for OSCC than those with genotype G/G (hazard ratio [HR], 0.26; 95{\%} confidence interval [CI], 0.10-0.60; p =.004). The overall survival between different SNPs were not statistically significant (p =.147 for rs1137282 and p =.202 for rs712). Conclusion These data demonstrate a role for rs712 polymorphism of the KRAS in susceptibility of OSCC.",
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Effects of KRAS mutation and polymorphism on the risk and prognosis of oral squamous cell carcinoma. / Wang, Wen Yi; Chien, Yi-Chih; Wong, Yong Kie; Lin, Yan Liang; Lin, Jin Ching.

In: Head and Neck, Vol. 34, No. 5, 01.05.2012, p. 663-666.

Research output: Contribution to journalArticle

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AU - Lin, Jin Ching

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N2 - Background Mutations or single nucleotide polymorphism (SNP) of relevant genes may affect the risk and prognosis of malignancies. The purpose of this study was to analyze whether the KRAS polymorphisms and mutations can be useful prognostic or risk markers in oral squamous cell carcinoma (OSCC). Methods DNA was extracted from tumor tissues of 47 patients with OSCC and blood cells of 84 normal controls and subjected to sequencing for the KRAS. Results No mutation in the KRAS was found in 47 OSCC samples. However, 2 polymorphisms (rs1137282 and rs712) were detected. Individuals with KRAS SNP rs712 genotypes of G/T or T/T have a reduced risk for OSCC than those with genotype G/G (hazard ratio [HR], 0.26; 95% confidence interval [CI], 0.10-0.60; p =.004). The overall survival between different SNPs were not statistically significant (p =.147 for rs1137282 and p =.202 for rs712). Conclusion These data demonstrate a role for rs712 polymorphism of the KRAS in susceptibility of OSCC.

AB - Background Mutations or single nucleotide polymorphism (SNP) of relevant genes may affect the risk and prognosis of malignancies. The purpose of this study was to analyze whether the KRAS polymorphisms and mutations can be useful prognostic or risk markers in oral squamous cell carcinoma (OSCC). Methods DNA was extracted from tumor tissues of 47 patients with OSCC and blood cells of 84 normal controls and subjected to sequencing for the KRAS. Results No mutation in the KRAS was found in 47 OSCC samples. However, 2 polymorphisms (rs1137282 and rs712) were detected. Individuals with KRAS SNP rs712 genotypes of G/T or T/T have a reduced risk for OSCC than those with genotype G/G (hazard ratio [HR], 0.26; 95% confidence interval [CI], 0.10-0.60; p =.004). The overall survival between different SNPs were not statistically significant (p =.147 for rs1137282 and p =.202 for rs712). Conclusion These data demonstrate a role for rs712 polymorphism of the KRAS in susceptibility of OSCC.

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