TY - JOUR
T1 - Drug delivery system design and development for boron neutron capture therapy on cancer treatment
AU - Sherlock Huang, Lin Chiang
AU - Hsieh, Wen Yuan
AU - Chen, Jiun Yu
AU - Huang, Su Chin
AU - Chen, Jen Kun
AU - Hsu, Ming Hua
PY - 2014/6
Y1 - 2014/6
N2 - We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,. l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.
AB - We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,. l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.
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U2 - 10.1016/j.apradiso.2013.12.025
DO - 10.1016/j.apradiso.2013.12.025
M3 - Article
C2 - 24447933
AN - SCOPUS:84901857533
VL - 88
SP - 89
EP - 93
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
ER -