Drug delivery system design and development for boron neutron capture therapy on cancer treatment

Lin Chiang Sherlock Huang, Wen Yuan Hsieh, Jiun Yu Chen, Su Chin Huang, Jen Kun Chen, Ming-Hua Hsu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,. l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalApplied Radiation and Isotopes
Volume88
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Boron Neutron Capture Therapy
Boron
Drug Delivery Systems
systems engineering
therapy
delivery
boron
drugs
cancer
neutrons
Neoplasms
copolymers
Micelles
Therapeutics
biocompatibility
Esters
caps
esters
micelles
Water

All Science Journal Classification (ASJC) codes

  • Radiation
  • Medicine(all)

Cite this

Sherlock Huang, Lin Chiang ; Hsieh, Wen Yuan ; Chen, Jiun Yu ; Huang, Su Chin ; Chen, Jen Kun ; Hsu, Ming-Hua. / Drug delivery system design and development for boron neutron capture therapy on cancer treatment. In: Applied Radiation and Isotopes. 2014 ; Vol. 88. pp. 89-93.
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Drug delivery system design and development for boron neutron capture therapy on cancer treatment. / Sherlock Huang, Lin Chiang; Hsieh, Wen Yuan; Chen, Jiun Yu; Huang, Su Chin; Chen, Jen Kun; Hsu, Ming-Hua.

In: Applied Radiation and Isotopes, Vol. 88, 01.01.2014, p. 89-93.

Research output: Contribution to journalArticle

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