Abstract
We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,. l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.
| Original language | English |
|---|---|
| Pages (from-to) | 89-93 |
| Number of pages | 5 |
| Journal | Applied Radiation and Isotopes |
| Volume | 88 |
| DOIs | |
| Publication status | Published - 2014 Jun |
All Science Journal Classification (ASJC) codes
- Radiation
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Cite this
Sherlock Huang, L. C., Hsieh, W. Y., Chen, J. Y., Huang, S. C., Chen, J. K., & Hsu, M. H. (2014). Drug delivery system design and development for boron neutron capture therapy on cancer treatment. Applied Radiation and Isotopes, 88, 89-93. https://doi.org/10.1016/j.apradiso.2013.12.025