Drug delivery system design and development for boron neutron capture therapy on cancer treatment

Lin Chiang Sherlock Huang; Wen Yuan Hsieh; Jiun Yu Chen; Su Chin Huang; Jen Kun Chen; Ming Hua Hsu

doi:10.1016/j.apradiso.2013.12.025

Drug delivery system design and development for boron neutron capture therapy on cancer treatment

Lin Chiang Sherlock Huang, Wen Yuan Hsieh, Jiun Yu Chen, Su Chin Huang, Jen Kun Chen, Ming Hua Hsu

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,. l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.

Original language	English
Pages (from-to)	89-93
Number of pages	5
Journal	Applied Radiation and Isotopes
Volume	88
DOIs	https://doi.org/10.1016/j.apradiso.2013.12.025
Publication status	Published - 2014 Jun

All Science Journal Classification (ASJC) codes

Radiation

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10.1016/j.apradiso.2013.12.025

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@article{2ae539896d8648f99c06b358247cf265,

title = "Drug delivery system design and development for boron neutron capture therapy on cancer treatment",

abstract = "We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,. l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.",

author = "{Sherlock Huang}, {Lin Chiang} and Hsieh, {Wen Yuan} and Chen, {Jiun Yu} and Huang, {Su Chin} and Chen, {Jen Kun} and Hsu, {Ming Hua}",

note = "Funding Information: For financial support, we thank the National Science Council ( NSC 100–2113-M-007–015-MY2 and 102–2113-M-007–010 ) and National Tsing Hua University. For the cell viability data, authors are grateful of financial support from National Health Research Institutes ( NM-100-PP-07 for JKC ) and National Science Council ( 101-2113-M-400-001-MY3 for JKC ).",

year = "2014",

month = jun,

doi = "10.1016/j.apradiso.2013.12.025",

language = "English",

volume = "88",

pages = "89--93",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Limited",

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T1 - Drug delivery system design and development for boron neutron capture therapy on cancer treatment

AU - Sherlock Huang, Lin Chiang

AU - Hsieh, Wen Yuan

AU - Chen, Jiun Yu

AU - Huang, Su Chin

AU - Chen, Jen Kun

AU - Hsu, Ming Hua

N1 - Funding Information: For financial support, we thank the National Science Council ( NSC 100–2113-M-007–015-MY2 and 102–2113-M-007–010 ) and National Tsing Hua University. For the cell viability data, authors are grateful of financial support from National Health Research Institutes ( NM-100-PP-07 for JKC ) and National Science Council ( 101-2113-M-400-001-MY3 for JKC ).

PY - 2014/6

Y1 - 2014/6

N2 - We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,. l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.

AB - We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,. l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.

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JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

SN - 0969-8043

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