Drug delivery system design and development for boron neutron capture therapy on cancer treatment

Lin Chiang Sherlock Huang; Wen Yuan Hsieh; Jiun Yu Chen; Su Chin Huang; Jen Kun Chen; Ming Hua Hsu

doi:10.1016/j.apradiso.2013.12.025

Drug delivery system design and development for boron neutron capture therapy on cancer treatment

Lin Chiang Sherlock Huang, Wen Yuan Hsieh, Jiun Yu Chen, Su Chin Huang, Jen Kun Chen, Ming Hua Hsu

Department of Chemistry

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,. l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.

Original language	English
Pages (from-to)	89-93
Number of pages	5
Journal	Applied Radiation and Isotopes
Volume	88
DOIs	https://doi.org/10.1016/j.apradiso.2013.12.025
Publication status	Published - 2014 Jun

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All Science Journal Classification (ASJC) codes

Radiation

Cite this

Sherlock Huang, L. C., Hsieh, W. Y., Chen, J. Y., Huang, S. C., Chen, J. K., & Hsu, M. H. (2014). Drug delivery system design and development for boron neutron capture therapy on cancer treatment. Applied Radiation and Isotopes, 88, 89-93. https://doi.org/10.1016/j.apradiso.2013.12.025

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abstract = "We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,. l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.",

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AU - Chen, Jen Kun

AU - Hsu, Ming Hua

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10.1016/j.apradiso.2013.12.025