Abstract
We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,. l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.
| Original language | English |
|---|---|
| Pages (from-to) | 89-93 |
| Number of pages | 5 |
| Journal | Applied Radiation and Isotopes |
| Volume | 88 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Radiation
- Medicine(all)
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Drug delivery system design and development for boron neutron capture therapy on cancer treatment. / Sherlock Huang, Lin Chiang; Hsieh, Wen Yuan; Chen, Jiun Yu; Huang, Su Chin; Chen, Jen Kun; Hsu, Ming-Hua.
In: Applied Radiation and Isotopes, Vol. 88, 01.01.2014, p. 89-93.Research output: Contribution to journal › Article
TY - JOUR
T1 - Drug delivery system design and development for boron neutron capture therapy on cancer treatment
AU - Sherlock Huang, Lin Chiang
AU - Hsieh, Wen Yuan
AU - Chen, Jiun Yu
AU - Huang, Su Chin
AU - Chen, Jen Kun
AU - Hsu, Ming-Hua
PY - 2014/1/1
Y1 - 2014/1/1
N2 - We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,. l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.
AB - We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,. l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.
UR - http://www.scopus.com/inward/record.url?scp=84901857533&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901857533&partnerID=8YFLogxK
U2 - 10.1016/j.apradiso.2013.12.025
DO - 10.1016/j.apradiso.2013.12.025
M3 - Article
C2 - 24447933
AN - SCOPUS:84901857533
VL - 88
SP - 89
EP - 93
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
ER -