Directly thiolated modification onto the surface of detonation nanodiamonds

Ming Hua Hsu, Hong Chuang, Fong Yu Cheng, Ying Pei Huang, Chien Chung Han, Jiun Yu Chen, Su Chin Huang, Jen Kun Chen, Dian Syue Wu, Hsueh Liang Chu, Chia Ching Chang

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

An efficient method for modifying the surface of detonation nanodiamonds (5 and 100 nm) with thiol groups (-SH) by using an organic chemistry strategy is presented herein. Thiolated nanodiamonds were characterized by spectroscopic techniques, and the atomic percentage of sulfur was analyzed by elemental analysis and X-ray photoelectron spectroscopy. The conjugation between thiolated nanodiamonds and gold nanoparticles was elucidated by transmission electron microscopy and UV-vis spectrometry. Moreover, the material did not show significant cytotoxicity to the human lung carcinoma cell line and may prospectively be applied in bioconjugated technology. The new method that we elucidated may significantly improve the approach to surface modification of detonation nanodiamonds and build up a new platform for the application of nanodiamonds.

Original languageEnglish
Pages (from-to)7198-7203
Number of pages6
JournalACS Applied Materials and Interfaces
Volume6
Issue number10
DOIs
Publication statusPublished - 2014 May 28

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Nanodiamonds
Detonation
Organic Chemistry
Photoelectron Spectroscopy
Cytotoxicity
Transmission Electron Microscopy
Sulfur
Sulfhydryl Compounds
Gold
Nanoparticles
Spectrometry
Surface treatment
Spectrum Analysis
X ray photoelectron spectroscopy
Cells
Transmission electron microscopy
Technology
Carcinoma
Cell Line
Lung

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Hsu, M. H., Chuang, H., Cheng, F. Y., Huang, Y. P., Han, C. C., Chen, J. Y., ... Chang, C. C. (2014). Directly thiolated modification onto the surface of detonation nanodiamonds. ACS Applied Materials and Interfaces, 6(10), 7198-7203. https://doi.org/10.1021/am500324z
Hsu, Ming Hua ; Chuang, Hong ; Cheng, Fong Yu ; Huang, Ying Pei ; Han, Chien Chung ; Chen, Jiun Yu ; Huang, Su Chin ; Chen, Jen Kun ; Wu, Dian Syue ; Chu, Hsueh Liang ; Chang, Chia Ching. / Directly thiolated modification onto the surface of detonation nanodiamonds. In: ACS Applied Materials and Interfaces. 2014 ; Vol. 6, No. 10. pp. 7198-7203.
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Hsu, MH, Chuang, H, Cheng, FY, Huang, YP, Han, CC, Chen, JY, Huang, SC, Chen, JK, Wu, DS, Chu, HL & Chang, CC 2014, 'Directly thiolated modification onto the surface of detonation nanodiamonds', ACS Applied Materials and Interfaces, vol. 6, no. 10, pp. 7198-7203. https://doi.org/10.1021/am500324z

Directly thiolated modification onto the surface of detonation nanodiamonds. / Hsu, Ming Hua; Chuang, Hong; Cheng, Fong Yu; Huang, Ying Pei; Han, Chien Chung; Chen, Jiun Yu; Huang, Su Chin; Chen, Jen Kun; Wu, Dian Syue; Chu, Hsueh Liang; Chang, Chia Ching.

In: ACS Applied Materials and Interfaces, Vol. 6, No. 10, 28.05.2014, p. 7198-7203.

Research output: Contribution to journalArticle

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AU - Hsu, Ming Hua

AU - Chuang, Hong

AU - Cheng, Fong Yu

AU - Huang, Ying Pei

AU - Han, Chien Chung

AU - Chen, Jiun Yu

AU - Huang, Su Chin

AU - Chen, Jen Kun

AU - Wu, Dian Syue

AU - Chu, Hsueh Liang

AU - Chang, Chia Ching

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AB - An efficient method for modifying the surface of detonation nanodiamonds (5 and 100 nm) with thiol groups (-SH) by using an organic chemistry strategy is presented herein. Thiolated nanodiamonds were characterized by spectroscopic techniques, and the atomic percentage of sulfur was analyzed by elemental analysis and X-ray photoelectron spectroscopy. The conjugation between thiolated nanodiamonds and gold nanoparticles was elucidated by transmission electron microscopy and UV-vis spectrometry. Moreover, the material did not show significant cytotoxicity to the human lung carcinoma cell line and may prospectively be applied in bioconjugated technology. The new method that we elucidated may significantly improve the approach to surface modification of detonation nanodiamonds and build up a new platform for the application of nanodiamonds.

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