Differentiation of remitting neuromyelitis optica spectrum disorders from multiple sclerosis by integrating parameters from serum proteins and lymphocyte subsets

Peng Peng Ip, Chen Yen Chung, Chien Ching Chang, Yu Fang Lee, Hui Min Wang, Ie Bin Lian, Cathy Shen Jang Fann, Chih Chao Yang, Fang Liao

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Differential diagnosis for neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) is always doubtful. To differentiate these diseases, we studied the immune status in the blood of patients with MS (n = 45) or NMOSD (n = 23) at remission phase. Remitting NMOSD patients had increased levels of CXCL13 and memory B cells, while remitting MS patients had elevated levels of galectin-9 and Th1 cells. A diagnostic model with these four variables is built to distinguish remitting NMOSD from MS with a sensitivity of 91.30%. Our diagnostic model may help to improve the differentiation of remitting NMOSD from MS.

Original languageEnglish
Pages (from-to)45-52
Number of pages8
JournalJournal of Neuroimmunology
Volume318
DOIs
Publication statusPublished - 2018 May 15

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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