Abstract
Differential diagnosis for neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) is always doubtful. To differentiate these diseases, we studied the immune status in the blood of patients with MS (n = 45) or NMOSD (n = 23) at remission phase. Remitting NMOSD patients had increased levels of CXCL13 and memory B cells, while remitting MS patients had elevated levels of galectin-9 and Th1 cells. A diagnostic model with these four variables is built to distinguish remitting NMOSD from MS with a sensitivity of 91.30%. Our diagnostic model may help to improve the differentiation of remitting NMOSD from MS.
| Original language | English |
|---|---|
| Pages (from-to) | 45-52 |
| Number of pages | 8 |
| Journal | Journal of Neuroimmunology |
| Volume | 318 |
| DOIs | |
| Publication status | Published - 2018 May 15 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology
Cite this
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Differentiation of remitting neuromyelitis optica spectrum disorders from multiple sclerosis by integrating parameters from serum proteins and lymphocyte subsets. / Ip, Peng Peng; Chung, Chen Yen; Chang, Chien Ching; Lee, Yu Fang; Wang, Hui Min; Lian, Iebin; Fann, Cathy Shen Jang; Yang, Chih Chao; Liao, Fang.
In: Journal of Neuroimmunology, Vol. 318, 15.05.2018, p. 45-52.Research output: Contribution to journal › Article
TY - JOUR
T1 - Differentiation of remitting neuromyelitis optica spectrum disorders from multiple sclerosis by integrating parameters from serum proteins and lymphocyte subsets
AU - Ip, Peng Peng
AU - Chung, Chen Yen
AU - Chang, Chien Ching
AU - Lee, Yu Fang
AU - Wang, Hui Min
AU - Lian, Iebin
AU - Fann, Cathy Shen Jang
AU - Yang, Chih Chao
AU - Liao, Fang
PY - 2018/5/15
Y1 - 2018/5/15
N2 - Differential diagnosis for neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) is always doubtful. To differentiate these diseases, we studied the immune status in the blood of patients with MS (n = 45) or NMOSD (n = 23) at remission phase. Remitting NMOSD patients had increased levels of CXCL13 and memory B cells, while remitting MS patients had elevated levels of galectin-9 and Th1 cells. A diagnostic model with these four variables is built to distinguish remitting NMOSD from MS with a sensitivity of 91.30%. Our diagnostic model may help to improve the differentiation of remitting NMOSD from MS.
AB - Differential diagnosis for neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) is always doubtful. To differentiate these diseases, we studied the immune status in the blood of patients with MS (n = 45) or NMOSD (n = 23) at remission phase. Remitting NMOSD patients had increased levels of CXCL13 and memory B cells, while remitting MS patients had elevated levels of galectin-9 and Th1 cells. A diagnostic model with these four variables is built to distinguish remitting NMOSD from MS with a sensitivity of 91.30%. Our diagnostic model may help to improve the differentiation of remitting NMOSD from MS.
UR - http://www.scopus.com/inward/record.url?scp=85042053258&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042053258&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2018.02.002
DO - 10.1016/j.jneuroim.2018.02.002
M3 - Article
VL - 318
SP - 45
EP - 52
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
ER -