Differentiation of remitting neuromyelitis optica spectrum disorders from multiple sclerosis by integrating parameters from serum proteins and lymphocyte subsets

Peng Peng Ip; Chen Yen Chung; Chien Ching Chang; Yu Fang Lee; Hui Min Wang; Ie Bin Lian; Cathy Shen Jang Fann; Chih Chao Yang; Fang Liao

doi:10.1016/j.jneuroim.2018.02.002

Differentiation of remitting neuromyelitis optica spectrum disorders from multiple sclerosis by integrating parameters from serum proteins and lymphocyte subsets

Peng Peng Ip, Chen Yen Chung, Chien Ching Chang, Yu Fang Lee, Hui Min Wang, Ie Bin Lian, Cathy Shen Jang Fann, Chih Chao Yang, Fang Liao

Graduate Institute of Statistics and Information Science

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

Differential diagnosis for neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) is always doubtful. To differentiate these diseases, we studied the immune status in the blood of patients with MS (n = 45) or NMOSD (n = 23) at remission phase. Remitting NMOSD patients had increased levels of CXCL13 and memory B cells, while remitting MS patients had elevated levels of galectin-9 and Th1 cells. A diagnostic model with these four variables is built to distinguish remitting NMOSD from MS with a sensitivity of 91.30%. Our diagnostic model may help to improve the differentiation of remitting NMOSD from MS.

Original language	English
Pages (from-to)	45-52
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	318
DOIs	https://doi.org/10.1016/j.jneuroim.2018.02.002
Publication status	Published - 2018 May 15

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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Ip, P. P., Chung, C. Y., Chang, C. C., Lee, Y. F., Wang, H. M., Lian, I. B., Fann, C. S. J., Yang, C. C., & Liao, F. (2018). Differentiation of remitting neuromyelitis optica spectrum disorders from multiple sclerosis by integrating parameters from serum proteins and lymphocyte subsets. Journal of Neuroimmunology, 318, 45-52. https://doi.org/10.1016/j.jneuroim.2018.02.002

Ip, Peng Peng ; Chung, Chen Yen ; Chang, Chien Ching ; Lee, Yu Fang ; Wang, Hui Min ; Lian, Ie Bin ; Fann, Cathy Shen Jang ; Yang, Chih Chao ; Liao, Fang. / Differentiation of remitting neuromyelitis optica spectrum disorders from multiple sclerosis by integrating parameters from serum proteins and lymphocyte subsets. In: Journal of Neuroimmunology. 2018 ; Vol. 318. pp. 45-52.

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title = "Differentiation of remitting neuromyelitis optica spectrum disorders from multiple sclerosis by integrating parameters from serum proteins and lymphocyte subsets",

abstract = "Differential diagnosis for neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) is always doubtful. To differentiate these diseases, we studied the immune status in the blood of patients with MS (n = 45) or NMOSD (n = 23) at remission phase. Remitting NMOSD patients had increased levels of CXCL13 and memory B cells, while remitting MS patients had elevated levels of galectin-9 and Th1 cells. A diagnostic model with these four variables is built to distinguish remitting NMOSD from MS with a sensitivity of 91.30%. Our diagnostic model may help to improve the differentiation of remitting NMOSD from MS.",

author = "Ip, {Peng Peng} and Chung, {Chen Yen} and Chang, {Chien Ching} and Lee, {Yu Fang} and Wang, {Hui Min} and Lian, {Ie Bin} and Fann, {Cathy Shen Jang} and Yang, {Chih Chao} and Fang Liao",

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Differentiation of remitting neuromyelitis optica spectrum disorders from multiple sclerosis by integrating parameters from serum proteins and lymphocyte subsets. / Ip, Peng Peng; Chung, Chen Yen; Chang, Chien Ching; Lee, Yu Fang; Wang, Hui Min; Lian, Ie Bin; Fann, Cathy Shen Jang; Yang, Chih Chao; Liao, Fang.

In: Journal of Neuroimmunology, Vol. 318, 15.05.2018, p. 45-52.

Research output: Contribution to journal › Article

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AU - Ip, Peng Peng

AU - Chung, Chen Yen

AU - Chang, Chien Ching

AU - Lee, Yu Fang

AU - Wang, Hui Min

AU - Lian, Ie Bin

AU - Fann, Cathy Shen Jang

AU - Yang, Chih Chao

AU - Liao, Fang

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AB - Differential diagnosis for neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) is always doubtful. To differentiate these diseases, we studied the immune status in the blood of patients with MS (n = 45) or NMOSD (n = 23) at remission phase. Remitting NMOSD patients had increased levels of CXCL13 and memory B cells, while remitting MS patients had elevated levels of galectin-9 and Th1 cells. A diagnostic model with these four variables is built to distinguish remitting NMOSD from MS with a sensitivity of 91.30%. Our diagnostic model may help to improve the differentiation of remitting NMOSD from MS.

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