TY - JOUR
T1 - Device-measured light-intensity physical activity and mortality
T2 - A meta-analysis
AU - Ku, Po Wen
AU - Hamer, Mark
AU - Liao, Yung
AU - Hsueh, Ming Chun
AU - Chen, Li Jung
N1 - Funding Information:
Funding information This study was funded by Taiwan Ministry of Science and Technology (MOST 107-2410-H-018-020; MOST 107-2420-H-002-007-MY3-Y10721). The funders had no role in the study design, data collection, data analysis and interpretation, or the content of the final manuscript. We would like to thank all authors who kindly provided additional data for the meta-analysis: Dr Koster, Dr Fox, Dr Edwards, Dr Lee PH, Dr Lee IM.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Introduction: The association of light-intensity physical activity (LPA) with mortality is poorly understood. This meta-analysis of cohort studies aimed to examine the dose-response relationships between daily device-measured LPA and mortality in adults aged 18 or older and to explore whether the associations were independent of moderate-to-vigorous physical activity (MVPA). Methods: Searches for prospective cohort studies providing effect estimates of daily LPA (exposure) on all-cause mortality (outcome) were systematically undertaken in electronic databases up to April 30, 2019. Subgroup analyses and meta-regression analyses with random-effects models were performed to quantify the dose-response relationships between daily LPA and mortality. Sensitivity analyses were also conducted to assess the stability of the results. Results: A total of 11 studies were included in the meta-analysis. Analyses contained 49 239 individuals (mean age 60.7, SD = 13.6) who were followed up for a mean 6.2 years (2.3-14.2 years), during which 3669 (7.5%) died. In comparison with the reference group (<3 h/d), the pooled HRs (and 95% CIs) of mortality were 0.71 (0.62-0.82), 0.68 (0.59-0.79), 0.56 (0.44-0.71) for groups 3 to <5 h/d, 5 to <7 h/d, and more than 7 hours a day LPA, respectively. Meta-regression models indicated that there was a log-cubic dose-response relationship between daily LPA and mortality in adults and older people, independent of MVPA. Conclusions: Time spent in daily LPA was associated with reduced risks of mortality in adults and older people. These data support the inclusion of LPA in the future physical activity guidelines.
AB - Introduction: The association of light-intensity physical activity (LPA) with mortality is poorly understood. This meta-analysis of cohort studies aimed to examine the dose-response relationships between daily device-measured LPA and mortality in adults aged 18 or older and to explore whether the associations were independent of moderate-to-vigorous physical activity (MVPA). Methods: Searches for prospective cohort studies providing effect estimates of daily LPA (exposure) on all-cause mortality (outcome) were systematically undertaken in electronic databases up to April 30, 2019. Subgroup analyses and meta-regression analyses with random-effects models were performed to quantify the dose-response relationships between daily LPA and mortality. Sensitivity analyses were also conducted to assess the stability of the results. Results: A total of 11 studies were included in the meta-analysis. Analyses contained 49 239 individuals (mean age 60.7, SD = 13.6) who were followed up for a mean 6.2 years (2.3-14.2 years), during which 3669 (7.5%) died. In comparison with the reference group (<3 h/d), the pooled HRs (and 95% CIs) of mortality were 0.71 (0.62-0.82), 0.68 (0.59-0.79), 0.56 (0.44-0.71) for groups 3 to <5 h/d, 5 to <7 h/d, and more than 7 hours a day LPA, respectively. Meta-regression models indicated that there was a log-cubic dose-response relationship between daily LPA and mortality in adults and older people, independent of MVPA. Conclusions: Time spent in daily LPA was associated with reduced risks of mortality in adults and older people. These data support the inclusion of LPA in the future physical activity guidelines.
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U2 - 10.1111/sms.13557
DO - 10.1111/sms.13557
M3 - Review article
C2 - 31545531
AN - SCOPUS:85073935478
VL - 30
SP - 13
EP - 24
JO - Scandinavian Journal of Medicine and Science in Sports
JF - Scandinavian Journal of Medicine and Science in Sports
SN - 0905-7188
IS - 1
ER -