Development of nordihydroguaiaretic acid derivatives as potential multidrug-resistant selective agents for cancer treatment

Lin Chiang Sherlock Huang, Hong Chuang, Mohit Kapoor, Cheng Ying Hsieh, Shih Ching Chou, Hui Hsien Lin, Yi Wei Chen, Chia Ching Chang, Jih Ru Hwu, Yu Chuan Liang, Ming-Hua Hsu

Research output: Contribution to journalArticle

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Abstract

In this research, we designed and synthesized a new series of nordihydroguaiaretic acid (NDGA) derivatives for multidrug resistance (MDR) research. A methylsulfonyl NDGA derivative, ((2R,3S)-2,3-dimethylbutane-1,4-diyl)bis(benzene-4,1,2-triyl) tetramethanesulfonate (5d), was found to inhibit MDR1 gene expression and suppress drug resistant MES-SA/Dx5 cells. Moreover, the combination of 5d and doxorubicin/terameprocol (M4N) showed a profound synergistic effect on inhibition of drug resistant cancer cells, suggesting that 5d is a potential adjuvant applied with doxorubicin or terameprocol in cancer treatment.

Original languageEnglish
Pages (from-to)107833-107838
Number of pages6
JournalRSC Advances
Volume5
Issue number130
DOIs
Publication statusPublished - 2015 Dec 15

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Masoprocol
Oncology
Doxorubicin
Derivatives
Acids
Benzene
Gene expression
Pharmaceutical Preparations
Cells
terameprocol
2,3-dimethylbutane

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Huang, Lin Chiang Sherlock ; Chuang, Hong ; Kapoor, Mohit ; Hsieh, Cheng Ying ; Chou, Shih Ching ; Lin, Hui Hsien ; Chen, Yi Wei ; Chang, Chia Ching ; Hwu, Jih Ru ; Liang, Yu Chuan ; Hsu, Ming-Hua. / Development of nordihydroguaiaretic acid derivatives as potential multidrug-resistant selective agents for cancer treatment. In: RSC Advances. 2015 ; Vol. 5, No. 130. pp. 107833-107838.
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Huang, LCS, Chuang, H, Kapoor, M, Hsieh, CY, Chou, SC, Lin, HH, Chen, YW, Chang, CC, Hwu, JR, Liang, YC & Hsu, M-H 2015, 'Development of nordihydroguaiaretic acid derivatives as potential multidrug-resistant selective agents for cancer treatment', RSC Advances, vol. 5, no. 130, pp. 107833-107838. https://doi.org/10.1039/c5ra18827j

Development of nordihydroguaiaretic acid derivatives as potential multidrug-resistant selective agents for cancer treatment. / Huang, Lin Chiang Sherlock; Chuang, Hong; Kapoor, Mohit; Hsieh, Cheng Ying; Chou, Shih Ching; Lin, Hui Hsien; Chen, Yi Wei; Chang, Chia Ching; Hwu, Jih Ru; Liang, Yu Chuan; Hsu, Ming-Hua.

In: RSC Advances, Vol. 5, No. 130, 15.12.2015, p. 107833-107838.

Research output: Contribution to journalArticle

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AU - Huang, Lin Chiang Sherlock

AU - Chuang, Hong

AU - Kapoor, Mohit

AU - Hsieh, Cheng Ying

AU - Chou, Shih Ching

AU - Lin, Hui Hsien

AU - Chen, Yi Wei

AU - Chang, Chia Ching

AU - Hwu, Jih Ru

AU - Liang, Yu Chuan

AU - Hsu, Ming-Hua

PY - 2015/12/15

Y1 - 2015/12/15

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