Development of nordihydroguaiaretic acid derivatives as potential multidrug-resistant selective agents for cancer treatment

Lin Chiang Sherlock Huang, Hong Chuang, Mohit Kapoor, Cheng Ying Hsieh, Shih Ching Chou, Hui Hsien Lin, Yi Wei Chen, Chia Ching Chang, Jih Ru Hwu, Yu Chuan Liang, Ming Hua Hsu

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4 Citations (Scopus)

Abstract

In this research, we designed and synthesized a new series of nordihydroguaiaretic acid (NDGA) derivatives for multidrug resistance (MDR) research. A methylsulfonyl NDGA derivative, ((2R,3S)-2,3-dimethylbutane-1,4-diyl)bis(benzene-4,1,2-triyl) tetramethanesulfonate (5d), was found to inhibit MDR1 gene expression and suppress drug resistant MES-SA/Dx5 cells. Moreover, the combination of 5d and doxorubicin/terameprocol (M4N) showed a profound synergistic effect on inhibition of drug resistant cancer cells, suggesting that 5d is a potential adjuvant applied with doxorubicin or terameprocol in cancer treatment.

Original languageEnglish
Pages (from-to)107833-107838
Number of pages6
JournalRSC Advances
Volume5
Issue number130
DOIs
Publication statusPublished - 2015 Dec 15

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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