Development of a leakage-free disposable package for biosensors immersed in the chemical solutions

Kuan Jung Chung, Chia Che Wu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

A leakage-free disposable package for biosensors was developed to improve the accuracy of electrochemical measurement. The traditional biosensor packaging such as diabetes test strip is not appropriate for the biosensor immersed in the chemical solution since it is easier to permeate through the layer between the substrate and the sensor chip to increase the errors of electrochemical impedance spectroscopy (EIS) measurement. It is possible to provide the incorrect diagnostic results to the patients. In this study, a novel package was designed and fabricated to solve this critical issue. Combined with the package-level flip chip and the assembly-level drilling technologies, the main advantage of the package is that the specific quantity of the chemical solution can be guided precisely into the cavity to react with the controlled region on the top side of the biosensor to stabilize the electrochemical reaction, and thus to increase the accuracy of the impedance measurement. The EIS results present the stable and smooth curves to verify the appropriate package design. Compared to the previous design by authors using traditional way of the front side gluing to the biosensor chip, the backside gluing is better to prevent the solution to flow into the sensor body, substrate, and the electrode so that it can increases the diagnostic accuracy corresponding to the sensitivity and specificity.

Original languageEnglish
Title of host publication2014 9th International Microsystems, Packaging, Assembly and Circuits Technology Conference
Subtitle of host publicationChallenges of Change - Shaping the Future, IMPACT 2014 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages488-490
Number of pages3
ISBN (Electronic)9781479977277
DOIs
Publication statusPublished - 2015 Feb 24
Event9th International Microsystems, Packaging, Assembly and Circuits Technology Conference, IMPACT 2014 - Taipei, Taiwan
Duration: 2014 Oct 222014 Oct 24

Other

Other9th International Microsystems, Packaging, Assembly and Circuits Technology Conference, IMPACT 2014
CountryTaiwan
CityTaipei
Period14-10-2214-10-24

Fingerprint

Biosensors
Gluing
Electrochemical impedance spectroscopy
Leakage (fluid)
Sensors
Substrates
Medical problems
Drilling
Packaging
Electrodes

All Science Journal Classification (ASJC) codes

  • Hardware and Architecture
  • Electrical and Electronic Engineering
  • Control and Systems Engineering

Cite this

Chung, K. J., & Wu, C. C. (2015). Development of a leakage-free disposable package for biosensors immersed in the chemical solutions. In 2014 9th International Microsystems, Packaging, Assembly and Circuits Technology Conference: Challenges of Change - Shaping the Future, IMPACT 2014 - Proceedings (pp. 488-490). [7048439] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/IMPACT.2014.7048439
Chung, Kuan Jung ; Wu, Chia Che. / Development of a leakage-free disposable package for biosensors immersed in the chemical solutions. 2014 9th International Microsystems, Packaging, Assembly and Circuits Technology Conference: Challenges of Change - Shaping the Future, IMPACT 2014 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2015. pp. 488-490
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Chung, KJ & Wu, CC 2015, Development of a leakage-free disposable package for biosensors immersed in the chemical solutions. in 2014 9th International Microsystems, Packaging, Assembly and Circuits Technology Conference: Challenges of Change - Shaping the Future, IMPACT 2014 - Proceedings., 7048439, Institute of Electrical and Electronics Engineers Inc., pp. 488-490, 9th International Microsystems, Packaging, Assembly and Circuits Technology Conference, IMPACT 2014, Taipei, Taiwan, 14-10-22. https://doi.org/10.1109/IMPACT.2014.7048439

Development of a leakage-free disposable package for biosensors immersed in the chemical solutions. / Chung, Kuan Jung; Wu, Chia Che.

2014 9th International Microsystems, Packaging, Assembly and Circuits Technology Conference: Challenges of Change - Shaping the Future, IMPACT 2014 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2015. p. 488-490 7048439.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Chung KJ, Wu CC. Development of a leakage-free disposable package for biosensors immersed in the chemical solutions. In 2014 9th International Microsystems, Packaging, Assembly and Circuits Technology Conference: Challenges of Change - Shaping the Future, IMPACT 2014 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2015. p. 488-490. 7048439 https://doi.org/10.1109/IMPACT.2014.7048439