Development of a growth-hormone-conjugated nanodiamond complex for cancer therapy

Hsueh Liang Chu, Hung Wei Chen, Shin Hua Tseng, Ming Hua Hsu, Li Ping Ho, Fu Hsuan Chou, Md Phd Hsing Yuan Li, Yu Chuan Chang, Pei Hsin Chen, Li Yun Tsai, Ching Chung Chou, Jyh Shin Chen, Tsai Mu Cheng, Chia Ching Chang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

It is highly desirable to develop a therapeutic, observable nanoparticle complex for specific targeting in cancer therapy. Growth hormone (GH) and its antagonists have been explored as cancer cell-targeting molecules for both imaging and therapeutic applications. In this study, a low toxicity, biocompatible, therapeutic, and observable GH-nanoparticle complex for specifically targeting growth hormone receptor (GHR) in cancer cells was synthesized by conjugating GH with green fluorescence protein and carboxylated nanodiamond. Moreover, we have shown that this complex can be triggered by laser irradiation to create a "nanoblast" and induce cell death in the A549 non-small-cell lung cancer cell line via the apoptotic pathway. This laser-mediated, cancer-targeting platform can be widely used in cancer therapy. Small but significant: A new nanosurgery platform was formed using a laser-mediated, cancer-targeting nanodiamond (ND) complex. Laser irradiation at 532 nm created a nanoblast of the ND complex and induced cell death within a growth-hormone-receptor-containing lung cancer cell line.

Original languageEnglish
Pages (from-to)1023-1029
Number of pages7
JournalChemMedChem
Volume9
Issue number5
DOIs
Publication statusPublished - 2014 May

Fingerprint

Nanodiamonds
Growth Hormone
Cells
Lasers
Somatotropin Receptors
Cell death
Laser beam effects
Neoplasms
Nanoparticles
Cell Death
Hormone Antagonists
Therapeutics
Cell Line
Toxicity
Non-Small Cell Lung Carcinoma
Fluorescence
Lung Neoplasms
Imaging techniques
Molecules

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Chu, H. L., Chen, H. W., Tseng, S. H., Hsu, M. H., Ho, L. P., Chou, F. H., ... Chang, C. C. (2014). Development of a growth-hormone-conjugated nanodiamond complex for cancer therapy. ChemMedChem, 9(5), 1023-1029. https://doi.org/10.1002/cmdc.201300541
Chu, Hsueh Liang ; Chen, Hung Wei ; Tseng, Shin Hua ; Hsu, Ming Hua ; Ho, Li Ping ; Chou, Fu Hsuan ; Li, Md Phd Hsing Yuan ; Chang, Yu Chuan ; Chen, Pei Hsin ; Tsai, Li Yun ; Chou, Ching Chung ; Chen, Jyh Shin ; Cheng, Tsai Mu ; Chang, Chia Ching. / Development of a growth-hormone-conjugated nanodiamond complex for cancer therapy. In: ChemMedChem. 2014 ; Vol. 9, No. 5. pp. 1023-1029.
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Chu, HL, Chen, HW, Tseng, SH, Hsu, MH, Ho, LP, Chou, FH, Li, MPHY, Chang, YC, Chen, PH, Tsai, LY, Chou, CC, Chen, JS, Cheng, TM & Chang, CC 2014, 'Development of a growth-hormone-conjugated nanodiamond complex for cancer therapy', ChemMedChem, vol. 9, no. 5, pp. 1023-1029. https://doi.org/10.1002/cmdc.201300541

Development of a growth-hormone-conjugated nanodiamond complex for cancer therapy. / Chu, Hsueh Liang; Chen, Hung Wei; Tseng, Shin Hua; Hsu, Ming Hua; Ho, Li Ping; Chou, Fu Hsuan; Li, Md Phd Hsing Yuan; Chang, Yu Chuan; Chen, Pei Hsin; Tsai, Li Yun; Chou, Ching Chung; Chen, Jyh Shin; Cheng, Tsai Mu; Chang, Chia Ching.

In: ChemMedChem, Vol. 9, No. 5, 05.2014, p. 1023-1029.

Research output: Contribution to journalArticle

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T1 - Development of a growth-hormone-conjugated nanodiamond complex for cancer therapy

AU - Chu, Hsueh Liang

AU - Chen, Hung Wei

AU - Tseng, Shin Hua

AU - Hsu, Ming Hua

AU - Ho, Li Ping

AU - Chou, Fu Hsuan

AU - Li, Md Phd Hsing Yuan

AU - Chang, Yu Chuan

AU - Chen, Pei Hsin

AU - Tsai, Li Yun

AU - Chou, Ching Chung

AU - Chen, Jyh Shin

AU - Cheng, Tsai Mu

AU - Chang, Chia Ching

PY - 2014/5

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