Determination of salicylic acid using a magnetic iron oxide nanoparticle-based solid-phase extraction procedure followed by an online concentration technique through micellar electrokinetic capillary chromatography

Yu Hsuan Chang, Chang Wei Huang, Shih-Feng Fu, Mei Yao Wu, Tsunghsueh Wu, Yang-Wei Lin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this study, a magnetic iron oxide nanoparticle-based solid-phase extraction procedure combined with the online concentration and separation of salicylic acid (SA) through micellar electrokinetic chromatography–UV detection (MEKC–UV) was developed. Under optimal experimental conditions, a good linearity in the range of 0.01–100 μmol L−1 was obtained with a coefficient of correlation of 0.9999. The detection sensitivity of the proposed method exhibited an approximately 1026-fold improvement compared with a single MEKC method without online concentration, and the detection limit (S/N = 3) was 3.80 nmol L−1. The repeatability of the method was evaluated using intraday and interday RSDs (11.5% and 17.0%, respectively). The method was used to determine SA concentrations in tobacco leaves (Nicotiana tabacum L. cv. Samsun) from the NN genotype, nn genotype, and Nt-NahG mutant strains, as well as in shampoo and ointment samples. Rapid extraction and separation ( < 50 min), acceptable repeatability (RSD < 17.0%), and high spiked recoveries (95.8%–102.4%) were observed for plants, detergents, and pharmaceuticals.

Original languageEnglish
Pages (from-to)62-70
Number of pages9
JournalJournal of Chromatography A
Volume1479
DOIs
Publication statusPublished - 2017 Jan 6

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Micellar Electrokinetic Capillary Chromatography
Salicylic Acid
Solid Phase Extraction
Chromatography
Nanoparticles
Tobacco
Ointments
Detergents
Recovery
Genotype
Pharmaceutical Preparations
Medicinal Plants
Limit of Detection
ferric oxide

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

Cite this

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title = "Determination of salicylic acid using a magnetic iron oxide nanoparticle-based solid-phase extraction procedure followed by an online concentration technique through micellar electrokinetic capillary chromatography",
abstract = "In this study, a magnetic iron oxide nanoparticle-based solid-phase extraction procedure combined with the online concentration and separation of salicylic acid (SA) through micellar electrokinetic chromatography–UV detection (MEKC–UV) was developed. Under optimal experimental conditions, a good linearity in the range of 0.01–100 μmol L−1 was obtained with a coefficient of correlation of 0.9999. The detection sensitivity of the proposed method exhibited an approximately 1026-fold improvement compared with a single MEKC method without online concentration, and the detection limit (S/N = 3) was 3.80 nmol L−1. The repeatability of the method was evaluated using intraday and interday RSDs (11.5{\%} and 17.0{\%}, respectively). The method was used to determine SA concentrations in tobacco leaves (Nicotiana tabacum L. cv. Samsun) from the NN genotype, nn genotype, and Nt-NahG mutant strains, as well as in shampoo and ointment samples. Rapid extraction and separation ( < 50 min), acceptable repeatability (RSD < 17.0{\%}), and high spiked recoveries (95.8{\%}–102.4{\%}) were observed for plants, detergents, and pharmaceuticals.",
author = "Chang, {Yu Hsuan} and Huang, {Chang Wei} and Shih-Feng Fu and Wu, {Mei Yao} and Tsunghsueh Wu and Yang-Wei Lin",
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T1 - Determination of salicylic acid using a magnetic iron oxide nanoparticle-based solid-phase extraction procedure followed by an online concentration technique through micellar electrokinetic capillary chromatography

AU - Chang, Yu Hsuan

AU - Huang, Chang Wei

AU - Fu, Shih-Feng

AU - Wu, Mei Yao

AU - Wu, Tsunghsueh

AU - Lin, Yang-Wei

PY - 2017/1/6

Y1 - 2017/1/6

N2 - In this study, a magnetic iron oxide nanoparticle-based solid-phase extraction procedure combined with the online concentration and separation of salicylic acid (SA) through micellar electrokinetic chromatography–UV detection (MEKC–UV) was developed. Under optimal experimental conditions, a good linearity in the range of 0.01–100 μmol L−1 was obtained with a coefficient of correlation of 0.9999. The detection sensitivity of the proposed method exhibited an approximately 1026-fold improvement compared with a single MEKC method without online concentration, and the detection limit (S/N = 3) was 3.80 nmol L−1. The repeatability of the method was evaluated using intraday and interday RSDs (11.5% and 17.0%, respectively). The method was used to determine SA concentrations in tobacco leaves (Nicotiana tabacum L. cv. Samsun) from the NN genotype, nn genotype, and Nt-NahG mutant strains, as well as in shampoo and ointment samples. Rapid extraction and separation ( < 50 min), acceptable repeatability (RSD < 17.0%), and high spiked recoveries (95.8%–102.4%) were observed for plants, detergents, and pharmaceuticals.

AB - In this study, a magnetic iron oxide nanoparticle-based solid-phase extraction procedure combined with the online concentration and separation of salicylic acid (SA) through micellar electrokinetic chromatography–UV detection (MEKC–UV) was developed. Under optimal experimental conditions, a good linearity in the range of 0.01–100 μmol L−1 was obtained with a coefficient of correlation of 0.9999. The detection sensitivity of the proposed method exhibited an approximately 1026-fold improvement compared with a single MEKC method without online concentration, and the detection limit (S/N = 3) was 3.80 nmol L−1. The repeatability of the method was evaluated using intraday and interday RSDs (11.5% and 17.0%, respectively). The method was used to determine SA concentrations in tobacco leaves (Nicotiana tabacum L. cv. Samsun) from the NN genotype, nn genotype, and Nt-NahG mutant strains, as well as in shampoo and ointment samples. Rapid extraction and separation ( < 50 min), acceptable repeatability (RSD < 17.0%), and high spiked recoveries (95.8%–102.4%) were observed for plants, detergents, and pharmaceuticals.

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