Design of delay-range-dependent robust controller for uncertain genetic regulatory networks with interval time-varying delays

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Abstract

This paper investigates the problem of robust stabilization for genetic regulatory networks with interval time-varying delays, which are subject to norm-bounded time-varying parameter uncertainties. The time delays including lower and upper bounds of delay are assumed to appear in both the mRNA and protein. The regulatory functions are assumed to be globally Lipschitz continuous. The resulting delay-range-dependent robust controller with interval range is designed in terms of improved bounding technique. A sufficient condition for the solvability of the problem is obtained via a linear matrix inequality (LMI). When this LMI is feasible, an explicit expression of a desired state feedback controller is also given. The theory developed in this paper is demonstrated by two numerical examples.

Original languageEnglish
Pages (from-to)234-245
Number of pages12
JournalAutomatic Control and Computer Sciences
Volume44
Issue number4
DOIs
Publication statusPublished - 2010 Aug 1

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Linear matrix inequalities
Controllers
State feedback
Time delay
Stabilization
Proteins
Uncertainty
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Software
  • Signal Processing

Cite this

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N2 - This paper investigates the problem of robust stabilization for genetic regulatory networks with interval time-varying delays, which are subject to norm-bounded time-varying parameter uncertainties. The time delays including lower and upper bounds of delay are assumed to appear in both the mRNA and protein. The regulatory functions are assumed to be globally Lipschitz continuous. The resulting delay-range-dependent robust controller with interval range is designed in terms of improved bounding technique. A sufficient condition for the solvability of the problem is obtained via a linear matrix inequality (LMI). When this LMI is feasible, an explicit expression of a desired state feedback controller is also given. The theory developed in this paper is demonstrated by two numerical examples.

AB - This paper investigates the problem of robust stabilization for genetic regulatory networks with interval time-varying delays, which are subject to norm-bounded time-varying parameter uncertainties. The time delays including lower and upper bounds of delay are assumed to appear in both the mRNA and protein. The regulatory functions are assumed to be globally Lipschitz continuous. The resulting delay-range-dependent robust controller with interval range is designed in terms of improved bounding technique. A sufficient condition for the solvability of the problem is obtained via a linear matrix inequality (LMI). When this LMI is feasible, an explicit expression of a desired state feedback controller is also given. The theory developed in this paper is demonstrated by two numerical examples.

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