Data mining application in biomedical informatics for probing into protein stability upon double mutation

Liang Tsung Huang, Chao Chin Wu, Lien Fu Lai, M. Michael Gromiha, Chang Sheng Wang, Yet Ran Chen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To explore the mechanism of protein stability change is one of the important topics in protein design. The accurate prediction of protein stability change upon mutation is very useful for enhancing the experimental efficiency in many biological and medical studies. In this work, we aimed at effectively introducing data mining technologies for investigating the understanding of protein stability change upon double mutation. We constructed a non-redundant dataset of protein mutants with various attributes and applied systematically analyses on the dataset. Therefore, we developed general knowledge from the dataset by several data mining techniques, including decision tree, decision table and association rule algorithms. Furthermore, we interpreted, evaluated, and compared those knowledge outcomes obtained from different techniques. The observations on the experimental results demonstrated that the present method may serve as an effective tool in biomedical informatics to understand the prediction of protein stability change upon double mutation.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalApplied Mathematics and Information Sciences
Volume8
Issue number1 L
DOIs
Publication statusPublished - 2014 Apr

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All Science Journal Classification (ASJC) codes

  • Analysis
  • Numerical Analysis
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Applied Mathematics

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