Colorimetric bioassay using noble metal nanoparticles

Ming Feng Huang, Yang-Wei Lin, Huan Tsung Chang

Research output: Chapter in Book/Report/Conference proceedingChapter


In this chapter, we attempt to present the development and applications of metal nanoparticle-based colorimetric assays. The sensing strategies are based on analyte-induced nanoparticle (NP) aggregation and dispersion. We begin with the preparation, stabilization, and surface functionalization of Au and Ag NPs. A general introduction of the optical properties of Au and Ag NPs briefly follows. After providing a general background, we concentrate on their applications of sensing analytes, including DNA, proteins, and small solutes, through interparticle crosslinking and noncrosslinking aggregation events.

Original languageEnglish
Title of host publicationFrom Bioimaging to Biosensors
Subtitle of host publicationNoble Metal Nanoparticles in Biodetection
PublisherPan Stanford Publishing Pte. Ltd.
Number of pages28
ISBN (Electronic)9789814303101
ISBN (Print)9789814267243
Publication statusPublished - 2012 Jan 1

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Engineering(all)
  • Materials Science(all)

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