Cognitive phenotypes in temporal lobe epilepsy

Bruce Hermann, Michael Seidenberg, Eun Jeong Lee, Fong Chan, Paul Rutecki

Research output: Contribution to journalArticlepeer-review

106 Citations (Scopus)


The objective of this study is to determine if distinct cognitive phenotypes could be identified in temporal lobe epilepsy. Epilepsy patients (n = 96) and healthy controls (n = 82) underwent comprehensive neuropsychological assessment. Adjusted (age, gender, and education) test scores for epilepsy subjects were grouped into cognitive domains (intelligence, language, visuoperception, immediate and delayed memory, executive function, and cognitive/psychomotor speed). Cluster analysis revealed three distinct cognitive profiles types: (1) minimally impaired (47% of subjects); (2) memory impaired (24%); and (3) memory, executive, and speed impaired (29%). The three cluster groups exhibited different patterns of results on demographic, clinical epilepsy, brain volumetrics, and cognitive course over a 4-year interval. The specific profile characteristics of the identified cognitive phenotypes are presented and their implications for the investigation of the neurobehavioral complications of epilepsy are discussed. (JINS, 2007, 13, 12-20.)

Original languageEnglish
Pages (from-to)12-20
Number of pages9
JournalJournal of the International Neuropsychological Society
Issue number1
Publication statusPublished - 2007 Jan

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

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