Chain-breaking activity of carotenes in lipid peroxidation: A theoretical study

Jian Jhih Guo, Hong Yi Hsieh, Ching-Han Hu

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Chain-breaking reactions against lipid peroxidation performed by carotenes, including β-carotene (β-CAR) and lycopene (LYC), have been studied using density functional theory. We chose linoleic acid (LAH) as the lipid model and examined two mechanisms: hydrogen abstraction and addition. Our computed reaction diagrams reveal that the addition mechanism is able to offer a larger extent of chain-breaking protection than hydrogen abstraction. In the case of hydrogen abstraction, the resulting carotene radical CAR(-H)' has a smaller O2 affinity than the linoleic acid radical (LȦ). Formation of the addition adduct radical ROO-CAṘ is energetically favorable, and it has an even smaller tendency to react with O2 than CAR(-H)̇. Comparatively, ROO-β-CAṘ is less likely to react with O2 than ROO-LYĊ. Both the hydrogen abstraction and addition radicals (CAR(-H)̇ and ROO-CAṘ) react readily with a second ROȮ radical via either hydrogen abstraction or addition.

Original languageEnglish
Pages (from-to)15699-15708
Number of pages10
JournalJournal of Physical Chemistry B
Volume113
Issue number47
DOIs
Publication statusPublished - 2009 Nov 26

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carotene
Carotenoids
Lipids
lipids
Hydrogen
hydrogen
Linoleic Acid
Linoleic acid
acids
adducts
Density functional theory
affinity
tendencies
diagrams
density functional theory

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this

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abstract = "Chain-breaking reactions against lipid peroxidation performed by carotenes, including β-carotene (β-CAR) and lycopene (LYC), have been studied using density functional theory. We chose linoleic acid (LAH) as the lipid model and examined two mechanisms: hydrogen abstraction and addition. Our computed reaction diagrams reveal that the addition mechanism is able to offer a larger extent of chain-breaking protection than hydrogen abstraction. In the case of hydrogen abstraction, the resulting carotene radical CAR(-H)' has a smaller O2 affinity than the linoleic acid radical (LȦ). Formation of the addition adduct radical ROO-CAṘ is energetically favorable, and it has an even smaller tendency to react with O2 than CAR(-H)̇. Comparatively, ROO-β-CAṘ is less likely to react with O2 than ROO-LYĊ. Both the hydrogen abstraction and addition radicals (CAR(-H)̇ and ROO-CAṘ) react readily with a second ROȮ radical via either hydrogen abstraction or addition.",
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Chain-breaking activity of carotenes in lipid peroxidation : A theoretical study. / Guo, Jian Jhih; Hsieh, Hong Yi; Hu, Ching-Han.

In: Journal of Physical Chemistry B, Vol. 113, No. 47, 26.11.2009, p. 15699-15708.

Research output: Contribution to journalArticle

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