Abstract
In this study, we tested the feasibility of using reverse micelles (RMs) as molecular crowding containers for DNA G-quadruplex. The results suggest that the RMs formed by anionic surfactants should be avoided for the molecular crowding studies of G-quadruplex structures. In contrast to the molecular crowding condition created by polyethylene glycol, the human telomeric sequence d[AG3(T2AG3)3] shows different conformations and drug binding stoichiometry in cationic RMs. Cationic RMs allow the DNA to avoid the dehydration effect caused by polyethylene glycol, and are therefore ideal containers for molecular crowding studies. This journal is
| Original language | English |
|---|---|
| Pages (from-to) | 20531-20534 |
| Number of pages | 4 |
| Journal | RSC Advances |
| Volume | 4 |
| Issue number | 39 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Chemical Engineering(all)
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Cationic and anionic reverse micelles as the molecular crowding container for G-quadruplex structure. / Ho, Meng Chieh; Chang, Chih-Wei.
In: RSC Advances, Vol. 4, No. 39, 01.01.2014, p. 20531-20534.Research output: Contribution to journal › Article
TY - JOUR
T1 - Cationic and anionic reverse micelles as the molecular crowding container for G-quadruplex structure
AU - Ho, Meng Chieh
AU - Chang, Chih-Wei
PY - 2014/1/1
Y1 - 2014/1/1
N2 - In this study, we tested the feasibility of using reverse micelles (RMs) as molecular crowding containers for DNA G-quadruplex. The results suggest that the RMs formed by anionic surfactants should be avoided for the molecular crowding studies of G-quadruplex structures. In contrast to the molecular crowding condition created by polyethylene glycol, the human telomeric sequence d[AG3(T2AG3)3] shows different conformations and drug binding stoichiometry in cationic RMs. Cationic RMs allow the DNA to avoid the dehydration effect caused by polyethylene glycol, and are therefore ideal containers for molecular crowding studies. This journal is
AB - In this study, we tested the feasibility of using reverse micelles (RMs) as molecular crowding containers for DNA G-quadruplex. The results suggest that the RMs formed by anionic surfactants should be avoided for the molecular crowding studies of G-quadruplex structures. In contrast to the molecular crowding condition created by polyethylene glycol, the human telomeric sequence d[AG3(T2AG3)3] shows different conformations and drug binding stoichiometry in cationic RMs. Cationic RMs allow the DNA to avoid the dehydration effect caused by polyethylene glycol, and are therefore ideal containers for molecular crowding studies. This journal is
UR - http://www.scopus.com/inward/record.url?scp=84901264796&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901264796&partnerID=8YFLogxK
U2 - 10.1039/c4ra02141j
DO - 10.1039/c4ra02141j
M3 - Article
AN - SCOPUS:84901264796
VL - 4
SP - 20531
EP - 20534
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 39
ER -