Cationic and anionic reverse micelles as the molecular crowding container for G-quadruplex structure

Meng Chieh Ho, Chih-Wei Chang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In this study, we tested the feasibility of using reverse micelles (RMs) as molecular crowding containers for DNA G-quadruplex. The results suggest that the RMs formed by anionic surfactants should be avoided for the molecular crowding studies of G-quadruplex structures. In contrast to the molecular crowding condition created by polyethylene glycol, the human telomeric sequence d[AG3(T2AG3)3] shows different conformations and drug binding stoichiometry in cationic RMs. Cationic RMs allow the DNA to avoid the dehydration effect caused by polyethylene glycol, and are therefore ideal containers for molecular crowding studies. This journal is

Original languageEnglish
Pages (from-to)20531-20534
Number of pages4
JournalRSC Advances
Volume4
Issue number39
DOIs
Publication statusPublished - 2014 Jan 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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