Bioactive chemical constituents from the brown alga homoeostrichus formosana

Hui Yu Fang, Uvarani Chokkalingam, Shu Fen Chiou, Tsong Long Hwang, Shu Li Chen, Wei Lung Wang, Jyh Horng Sheu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A new chromene derivative, 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-hydroxy-2,6-dimethyl-2H-chromene (1) together with four known natural products, methylfarnesylquinone (2), isololiolide (3), pheophytin a (4), and β-carotene (5) were isolated from the brown alga Homoeostrichus formosana. The structure of 1 was determined by extensive 1D and 2D spectroscopic analyses. Acetylation of 1 yielded the monoacetylated derivative 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-acetyl-2,6-dimethyl-2H-chromene (6). Compounds 1–6 exhibited various levels of cytotoxic, antibacterial, and anti-inflammatory activities. Compound 2 was found to display potent in vitro anti-inflammatory activity by inhibiting the generation of superoxide anion (IC50 0.22 ± 0.03 μg/mL) and elastase release (IC50 0.48 ± 0.11 μg/mL) in FMLP/CB-induced human neutrophils.

Original languageEnglish
Pages (from-to)736-746
Number of pages11
JournalInternational Journal of Molecular Sciences
Volume16
Issue number1
DOIs
Publication statusPublished - 2015 Dec 30

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Phaeophyta
algae
Algae
activity (biology)
Inhibitory Concentration 50
Anti-Inflammatory Agents
neutrophils
acetylation
Derivatives
Benzopyrans
Acetylation
carotene
inorganic peroxides
Pancreatic Elastase
Carotenoids
Biological Products
Superoxides
Neutrophils
Negative ions
anions

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Fang, H. Y., Chokkalingam, U., Chiou, S. F., Hwang, T. L., Chen, S. L., Wang, W. L., & Sheu, J. H. (2015). Bioactive chemical constituents from the brown alga homoeostrichus formosana. International Journal of Molecular Sciences, 16(1), 736-746. https://doi.org/10.3390/ijms16010736
Fang, Hui Yu ; Chokkalingam, Uvarani ; Chiou, Shu Fen ; Hwang, Tsong Long ; Chen, Shu Li ; Wang, Wei Lung ; Sheu, Jyh Horng. / Bioactive chemical constituents from the brown alga homoeostrichus formosana. In: International Journal of Molecular Sciences. 2015 ; Vol. 16, No. 1. pp. 736-746.
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abstract = "A new chromene derivative, 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-hydroxy-2,6-dimethyl-2H-chromene (1) together with four known natural products, methylfarnesylquinone (2), isololiolide (3), pheophytin a (4), and β-carotene (5) were isolated from the brown alga Homoeostrichus formosana. The structure of 1 was determined by extensive 1D and 2D spectroscopic analyses. Acetylation of 1 yielded the monoacetylated derivative 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-acetyl-2,6-dimethyl-2H-chromene (6). Compounds 1–6 exhibited various levels of cytotoxic, antibacterial, and anti-inflammatory activities. Compound 2 was found to display potent in vitro anti-inflammatory activity by inhibiting the generation of superoxide anion (IC50 0.22 ± 0.03 μg/mL) and elastase release (IC50 0.48 ± 0.11 μg/mL) in FMLP/CB-induced human neutrophils.",
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Fang, HY, Chokkalingam, U, Chiou, SF, Hwang, TL, Chen, SL, Wang, WL & Sheu, JH 2015, 'Bioactive chemical constituents from the brown alga homoeostrichus formosana', International Journal of Molecular Sciences, vol. 16, no. 1, pp. 736-746. https://doi.org/10.3390/ijms16010736

Bioactive chemical constituents from the brown alga homoeostrichus formosana. / Fang, Hui Yu; Chokkalingam, Uvarani; Chiou, Shu Fen; Hwang, Tsong Long; Chen, Shu Li; Wang, Wei Lung; Sheu, Jyh Horng.

In: International Journal of Molecular Sciences, Vol. 16, No. 1, 30.12.2015, p. 736-746.

Research output: Contribution to journalArticle

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AU - Chiou, Shu Fen

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AU - Wang, Wei Lung

AU - Sheu, Jyh Horng

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