Bioactive chemical constituents from the brown alga homoeostrichus formosana

Hui Yu Fang, Uvarani Chokkalingam, Shu Fen Chiou, Tsong Long Hwang, Shu Li Chen, Wei Lung Wang, Jyh Horng Sheu

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Abstract

A new chromene derivative, 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-hydroxy-2,6-dimethyl-2H-chromene (1) together with four known natural products, methylfarnesylquinone (2), isololiolide (3), pheophytin a (4), and β-carotene (5) were isolated from the brown alga Homoeostrichus formosana. The structure of 1 was determined by extensive 1D and 2D spectroscopic analyses. Acetylation of 1 yielded the monoacetylated derivative 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-acetyl-2,6-dimethyl-2H-chromene (6). Compounds 1–6 exhibited various levels of cytotoxic, antibacterial, and anti-inflammatory activities. Compound 2 was found to display potent in vitro anti-inflammatory activity by inhibiting the generation of superoxide anion (IC50 0.22 ± 0.03 μg/mL) and elastase release (IC50 0.48 ± 0.11 μg/mL) in FMLP/CB-induced human neutrophils.

Original languageEnglish
Pages (from-to)736-746
Number of pages11
JournalInternational Journal of Molecular Sciences
Volume16
Issue number1
DOIs
Publication statusPublished - 2015 Dec 30

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Fang, H. Y., Chokkalingam, U., Chiou, S. F., Hwang, T. L., Chen, S. L., Wang, W. L., & Sheu, J. H. (2015). Bioactive chemical constituents from the brown alga homoeostrichus formosana. International Journal of Molecular Sciences, 16(1), 736-746. https://doi.org/10.3390/ijms16010736