Benign prostatic hyperplasia complicated with T1DM can be alleviated by treadmill exercise - evidences revealed by the rat model Voiding dysfunction

Kuan Chou Chen, Shian Ying Sung, Yi Ting Lin, Chiu-Lan Hsieh, Kun Hung Shen, Chiung Chi Peng, Robert Y. Peng

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Both benign prostatic hyperplasia (BPH) and Type-1 diabetes mellitus (T1DM) share similar epidemiologic features and are all associated with the insulin-like growth factor (IGF)-mediated hormonal imbalance. The purpose of this study is to understand whether exercise (EX) could alleviate DM and DM + BPH. Methods: Sprague-Dawley rats were divided into eight groups: normal control, EX, BPH, BPH + EX, DM, DM + EX, BPH + DM, and BPH + DM + EX. T1DM was induced by intraperitoneal (ip) injection of streptozotocin (65 mg/kg) in Week 2, and BPH was induced by successive ip injections of Sustanon® (testosterone, 3.5 mg/head) plus estradiol (0.1 mg/head) from Week 3 to Week 9. Treadmill exercise training (20 m/min, 60 min per time) was performed three times per week for 6 weeks. Results: In BPH + EX, EX maintained at a constant body weight (BW); and suppressed stromal layer thickening, collagen deposition, blood glucose (BG), levels of testosterone (Ts), 5α-reductase(5αRd), dihydrotestosterone (DHT), androgen receptor (AR), serum hydrogen peroxide, TBARs, and interleukin-6 (IL-6). EX recovered testes size and substantially increased nitric oxide (NO) levels. In DM + EX group, EX decreased BW, PW, nuclear proliferation, inflammatory cell aggregation, collagen deposition, and BG. As contrast, EX upregulated insulin, IGF, Ts, NO, 5αRd, AR, and DHT, and substantially reduced PSA. In BPH + DM + EX, EX maintained BW at a subnormal level, slightly suppressed prostate stromal inflammation, collagen deposition, and BG, moderately restored sIn and IGF. Although failed to suppress Ts, EX highly upregulated 5αRd and suppressed DHT and AR, together with highly upregulated NO resulting in substantially reduced PSA. Conclusion: EX, by remodeling androgen and NO expressions, can effectively alleviate BPH, DM, and BPH + DM.

Original languageEnglish
Article number104
JournalBMC Urology
Volume15
Issue number1
DOIs
Publication statusPublished - 2015 Nov 17

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Prostatic Hyperplasia
Type 1 Diabetes Mellitus
Androgen Receptors
Testosterone
Somatomedins
Blood Glucose
Nitric Oxide
Collagen
Body Weight
Intraperitoneal Injections
Oxidoreductases
Head
Cell Aggregation
Thiobarbituric Acid Reactive Substances
Dihydrotestosterone
Streptozocin
Hydrogen Peroxide
Androgens
Sprague Dawley Rats
Testis

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Urology

Cite this

Chen, Kuan Chou ; Sung, Shian Ying ; Lin, Yi Ting ; Hsieh, Chiu-Lan ; Shen, Kun Hung ; Peng, Chiung Chi ; Peng, Robert Y. / Benign prostatic hyperplasia complicated with T1DM can be alleviated by treadmill exercise - evidences revealed by the rat model Voiding dysfunction. In: BMC Urology. 2015 ; Vol. 15, No. 1.
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abstract = "Background: Both benign prostatic hyperplasia (BPH) and Type-1 diabetes mellitus (T1DM) share similar epidemiologic features and are all associated with the insulin-like growth factor (IGF)-mediated hormonal imbalance. The purpose of this study is to understand whether exercise (EX) could alleviate DM and DM + BPH. Methods: Sprague-Dawley rats were divided into eight groups: normal control, EX, BPH, BPH + EX, DM, DM + EX, BPH + DM, and BPH + DM + EX. T1DM was induced by intraperitoneal (ip) injection of streptozotocin (65 mg/kg) in Week 2, and BPH was induced by successive ip injections of Sustanon{\circledR} (testosterone, 3.5 mg/head) plus estradiol (0.1 mg/head) from Week 3 to Week 9. Treadmill exercise training (20 m/min, 60 min per time) was performed three times per week for 6 weeks. Results: In BPH + EX, EX maintained at a constant body weight (BW); and suppressed stromal layer thickening, collagen deposition, blood glucose (BG), levels of testosterone (Ts), 5α-reductase(5αRd), dihydrotestosterone (DHT), androgen receptor (AR), serum hydrogen peroxide, TBARs, and interleukin-6 (IL-6). EX recovered testes size and substantially increased nitric oxide (NO) levels. In DM + EX group, EX decreased BW, PW, nuclear proliferation, inflammatory cell aggregation, collagen deposition, and BG. As contrast, EX upregulated insulin, IGF, Ts, NO, 5αRd, AR, and DHT, and substantially reduced PSA. In BPH + DM + EX, EX maintained BW at a subnormal level, slightly suppressed prostate stromal inflammation, collagen deposition, and BG, moderately restored sIn and IGF. Although failed to suppress Ts, EX highly upregulated 5αRd and suppressed DHT and AR, together with highly upregulated NO resulting in substantially reduced PSA. Conclusion: EX, by remodeling androgen and NO expressions, can effectively alleviate BPH, DM, and BPH + DM.",
author = "Chen, {Kuan Chou} and Sung, {Shian Ying} and Lin, {Yi Ting} and Chiu-Lan Hsieh and Shen, {Kun Hung} and Peng, {Chiung Chi} and Peng, {Robert Y.}",
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Benign prostatic hyperplasia complicated with T1DM can be alleviated by treadmill exercise - evidences revealed by the rat model Voiding dysfunction. / Chen, Kuan Chou; Sung, Shian Ying; Lin, Yi Ting; Hsieh, Chiu-Lan; Shen, Kun Hung; Peng, Chiung Chi; Peng, Robert Y.

In: BMC Urology, Vol. 15, No. 1, 104, 17.11.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Benign prostatic hyperplasia complicated with T1DM can be alleviated by treadmill exercise - evidences revealed by the rat model Voiding dysfunction

AU - Chen, Kuan Chou

AU - Sung, Shian Ying

AU - Lin, Yi Ting

AU - Hsieh, Chiu-Lan

AU - Shen, Kun Hung

AU - Peng, Chiung Chi

AU - Peng, Robert Y.

PY - 2015/11/17

Y1 - 2015/11/17

N2 - Background: Both benign prostatic hyperplasia (BPH) and Type-1 diabetes mellitus (T1DM) share similar epidemiologic features and are all associated with the insulin-like growth factor (IGF)-mediated hormonal imbalance. The purpose of this study is to understand whether exercise (EX) could alleviate DM and DM + BPH. Methods: Sprague-Dawley rats were divided into eight groups: normal control, EX, BPH, BPH + EX, DM, DM + EX, BPH + DM, and BPH + DM + EX. T1DM was induced by intraperitoneal (ip) injection of streptozotocin (65 mg/kg) in Week 2, and BPH was induced by successive ip injections of Sustanon® (testosterone, 3.5 mg/head) plus estradiol (0.1 mg/head) from Week 3 to Week 9. Treadmill exercise training (20 m/min, 60 min per time) was performed three times per week for 6 weeks. Results: In BPH + EX, EX maintained at a constant body weight (BW); and suppressed stromal layer thickening, collagen deposition, blood glucose (BG), levels of testosterone (Ts), 5α-reductase(5αRd), dihydrotestosterone (DHT), androgen receptor (AR), serum hydrogen peroxide, TBARs, and interleukin-6 (IL-6). EX recovered testes size and substantially increased nitric oxide (NO) levels. In DM + EX group, EX decreased BW, PW, nuclear proliferation, inflammatory cell aggregation, collagen deposition, and BG. As contrast, EX upregulated insulin, IGF, Ts, NO, 5αRd, AR, and DHT, and substantially reduced PSA. In BPH + DM + EX, EX maintained BW at a subnormal level, slightly suppressed prostate stromal inflammation, collagen deposition, and BG, moderately restored sIn and IGF. Although failed to suppress Ts, EX highly upregulated 5αRd and suppressed DHT and AR, together with highly upregulated NO resulting in substantially reduced PSA. Conclusion: EX, by remodeling androgen and NO expressions, can effectively alleviate BPH, DM, and BPH + DM.

AB - Background: Both benign prostatic hyperplasia (BPH) and Type-1 diabetes mellitus (T1DM) share similar epidemiologic features and are all associated with the insulin-like growth factor (IGF)-mediated hormonal imbalance. The purpose of this study is to understand whether exercise (EX) could alleviate DM and DM + BPH. Methods: Sprague-Dawley rats were divided into eight groups: normal control, EX, BPH, BPH + EX, DM, DM + EX, BPH + DM, and BPH + DM + EX. T1DM was induced by intraperitoneal (ip) injection of streptozotocin (65 mg/kg) in Week 2, and BPH was induced by successive ip injections of Sustanon® (testosterone, 3.5 mg/head) plus estradiol (0.1 mg/head) from Week 3 to Week 9. Treadmill exercise training (20 m/min, 60 min per time) was performed three times per week for 6 weeks. Results: In BPH + EX, EX maintained at a constant body weight (BW); and suppressed stromal layer thickening, collagen deposition, blood glucose (BG), levels of testosterone (Ts), 5α-reductase(5αRd), dihydrotestosterone (DHT), androgen receptor (AR), serum hydrogen peroxide, TBARs, and interleukin-6 (IL-6). EX recovered testes size and substantially increased nitric oxide (NO) levels. In DM + EX group, EX decreased BW, PW, nuclear proliferation, inflammatory cell aggregation, collagen deposition, and BG. As contrast, EX upregulated insulin, IGF, Ts, NO, 5αRd, AR, and DHT, and substantially reduced PSA. In BPH + DM + EX, EX maintained BW at a subnormal level, slightly suppressed prostate stromal inflammation, collagen deposition, and BG, moderately restored sIn and IGF. Although failed to suppress Ts, EX highly upregulated 5αRd and suppressed DHT and AR, together with highly upregulated NO resulting in substantially reduced PSA. Conclusion: EX, by remodeling androgen and NO expressions, can effectively alleviate BPH, DM, and BPH + DM.

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