Abstract
Objectives: Metabolic factors are major risk factors for non-alcoholic fatty liver disease although other factors may also contribute to development of fatty liver disease. We explored the association between exposure to soil heavy metals and prevalence of fatty liver disease. Methods: We retrospectively analysed data from patients diagnosed with fatty liver disease in 2014 at the Health Evaluation Centre of Chang-Hua Christian Hospital (n=1137). We used residency data provided in the records of the Health Evaluation Centre and data for soil metal concentrations from a nationwide survey conducted by the Environmental Protection Administration of Taiwan. We studied the correlations between the severity of fatty liver disease and concentrations of soil heavy metals (arsenic, mercury, cadmium, chromium, copper, nickel, lead and zinc). Results: The prevalence of moderate to severe fatty liver disease in our study was 26.5%. Using univariate and multivariate analysis, we demonstrated that the presence of soil heavy metals was a significant risk factor for fatty liver disease in men (OR 1.83, 95% CI 1.161 to 2.899, p=0.009). With stratification by body mass index (BMI) and gender, lean men with a BMI <24 kg/m2 were the most susceptible to soil heavy metals (OR 5.059, 95% CI 1.628 to 15.728, p<0.05). Conclusions: Our study suggested a significant association between exposure to soil heavy metals and fatty liver disease in lean men.
| Original language | English |
|---|---|
| Article number | e014215 |
| Journal | BMJ Open |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2017 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Association between soil heavy metals and fatty liver disease in men in Taiwan : A cross sectional study. / Lin, Yen Chih; Lian, Ie Bin; Kor, Chew Teng; Chang, Chia Chu; Su, Pei Yuan; Chang, Wan Tzu; Liang, Yu Fen; Su, Wei Wen; Soon, Maw Soan.
In: BMJ Open, Vol. 7, No. 1, e014215, 01.01.2017.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association between soil heavy metals and fatty liver disease in men in Taiwan
T2 - A cross sectional study
AU - Lin, Yen Chih
AU - Lian, Ie Bin
AU - Kor, Chew Teng
AU - Chang, Chia Chu
AU - Su, Pei Yuan
AU - Chang, Wan Tzu
AU - Liang, Yu Fen
AU - Su, Wei Wen
AU - Soon, Maw Soan
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objectives: Metabolic factors are major risk factors for non-alcoholic fatty liver disease although other factors may also contribute to development of fatty liver disease. We explored the association between exposure to soil heavy metals and prevalence of fatty liver disease. Methods: We retrospectively analysed data from patients diagnosed with fatty liver disease in 2014 at the Health Evaluation Centre of Chang-Hua Christian Hospital (n=1137). We used residency data provided in the records of the Health Evaluation Centre and data for soil metal concentrations from a nationwide survey conducted by the Environmental Protection Administration of Taiwan. We studied the correlations between the severity of fatty liver disease and concentrations of soil heavy metals (arsenic, mercury, cadmium, chromium, copper, nickel, lead and zinc). Results: The prevalence of moderate to severe fatty liver disease in our study was 26.5%. Using univariate and multivariate analysis, we demonstrated that the presence of soil heavy metals was a significant risk factor for fatty liver disease in men (OR 1.83, 95% CI 1.161 to 2.899, p=0.009). With stratification by body mass index (BMI) and gender, lean men with a BMI <24 kg/m2 were the most susceptible to soil heavy metals (OR 5.059, 95% CI 1.628 to 15.728, p<0.05). Conclusions: Our study suggested a significant association between exposure to soil heavy metals and fatty liver disease in lean men.
AB - Objectives: Metabolic factors are major risk factors for non-alcoholic fatty liver disease although other factors may also contribute to development of fatty liver disease. We explored the association between exposure to soil heavy metals and prevalence of fatty liver disease. Methods: We retrospectively analysed data from patients diagnosed with fatty liver disease in 2014 at the Health Evaluation Centre of Chang-Hua Christian Hospital (n=1137). We used residency data provided in the records of the Health Evaluation Centre and data for soil metal concentrations from a nationwide survey conducted by the Environmental Protection Administration of Taiwan. We studied the correlations between the severity of fatty liver disease and concentrations of soil heavy metals (arsenic, mercury, cadmium, chromium, copper, nickel, lead and zinc). Results: The prevalence of moderate to severe fatty liver disease in our study was 26.5%. Using univariate and multivariate analysis, we demonstrated that the presence of soil heavy metals was a significant risk factor for fatty liver disease in men (OR 1.83, 95% CI 1.161 to 2.899, p=0.009). With stratification by body mass index (BMI) and gender, lean men with a BMI <24 kg/m2 were the most susceptible to soil heavy metals (OR 5.059, 95% CI 1.628 to 15.728, p<0.05). Conclusions: Our study suggested a significant association between exposure to soil heavy metals and fatty liver disease in lean men.
UR - http://www.scopus.com/inward/record.url?scp=85010468241&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85010468241&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2016-014215
DO - 10.1136/bmjopen-2016-014215
M3 - Article
C2 - 28115335
AN - SCOPUS:85010468241
VL - 7
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 1
M1 - e014215
ER -