Association between soil heavy metals and fatty liver disease in men in Taiwan: A cross sectional study

Yen Chih Lin, Ie Bin Lian, Chew Teng Kor, Chia Chu Chang, Pei Yuan Su, Wan Tzu Chang, Yu Fen Liang, Wei Wen Su, Maw Soan Soon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives: Metabolic factors are major risk factors for non-alcoholic fatty liver disease although other factors may also contribute to development of fatty liver disease. We explored the association between exposure to soil heavy metals and prevalence of fatty liver disease. Methods: We retrospectively analysed data from patients diagnosed with fatty liver disease in 2014 at the Health Evaluation Centre of Chang-Hua Christian Hospital (n=1137). We used residency data provided in the records of the Health Evaluation Centre and data for soil metal concentrations from a nationwide survey conducted by the Environmental Protection Administration of Taiwan. We studied the correlations between the severity of fatty liver disease and concentrations of soil heavy metals (arsenic, mercury, cadmium, chromium, copper, nickel, lead and zinc). Results: The prevalence of moderate to severe fatty liver disease in our study was 26.5%. Using univariate and multivariate analysis, we demonstrated that the presence of soil heavy metals was a significant risk factor for fatty liver disease in men (OR 1.83, 95% CI 1.161 to 2.899, p=0.009). With stratification by body mass index (BMI) and gender, lean men with a BMI <24 kg/m2 were the most susceptible to soil heavy metals (OR 5.059, 95% CI 1.628 to 15.728, p<0.05). Conclusions: Our study suggested a significant association between exposure to soil heavy metals and fatty liver disease in lean men.

Original languageEnglish
Article numbere014215
JournalBMJ Open
Volume7
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

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Fatty Liver
Heavy Metals
Taiwan
Liver Diseases
Soil
Cross-Sectional Studies
Body Mass Index
Conservation of Natural Resources
Health
Arsenic
Chromium
Internship and Residency
Nickel
Mercury
Cadmium
Zinc
Copper
Multivariate Analysis
Metals

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lin, Yen Chih ; Lian, Ie Bin ; Kor, Chew Teng ; Chang, Chia Chu ; Su, Pei Yuan ; Chang, Wan Tzu ; Liang, Yu Fen ; Su, Wei Wen ; Soon, Maw Soan. / Association between soil heavy metals and fatty liver disease in men in Taiwan : A cross sectional study. In: BMJ Open. 2017 ; Vol. 7, No. 1.
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abstract = "Objectives: Metabolic factors are major risk factors for non-alcoholic fatty liver disease although other factors may also contribute to development of fatty liver disease. We explored the association between exposure to soil heavy metals and prevalence of fatty liver disease. Methods: We retrospectively analysed data from patients diagnosed with fatty liver disease in 2014 at the Health Evaluation Centre of Chang-Hua Christian Hospital (n=1137). We used residency data provided in the records of the Health Evaluation Centre and data for soil metal concentrations from a nationwide survey conducted by the Environmental Protection Administration of Taiwan. We studied the correlations between the severity of fatty liver disease and concentrations of soil heavy metals (arsenic, mercury, cadmium, chromium, copper, nickel, lead and zinc). Results: The prevalence of moderate to severe fatty liver disease in our study was 26.5{\%}. Using univariate and multivariate analysis, we demonstrated that the presence of soil heavy metals was a significant risk factor for fatty liver disease in men (OR 1.83, 95{\%} CI 1.161 to 2.899, p=0.009). With stratification by body mass index (BMI) and gender, lean men with a BMI <24 kg/m2 were the most susceptible to soil heavy metals (OR 5.059, 95{\%} CI 1.628 to 15.728, p<0.05). Conclusions: Our study suggested a significant association between exposure to soil heavy metals and fatty liver disease in lean men.",
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Lin, YC, Lian, IB, Kor, CT, Chang, CC, Su, PY, Chang, WT, Liang, YF, Su, WW & Soon, MS 2017, 'Association between soil heavy metals and fatty liver disease in men in Taiwan: A cross sectional study', BMJ Open, vol. 7, no. 1, e014215. https://doi.org/10.1136/bmjopen-2016-014215

Association between soil heavy metals and fatty liver disease in men in Taiwan : A cross sectional study. / Lin, Yen Chih; Lian, Ie Bin; Kor, Chew Teng; Chang, Chia Chu; Su, Pei Yuan; Chang, Wan Tzu; Liang, Yu Fen; Su, Wei Wen; Soon, Maw Soan.

In: BMJ Open, Vol. 7, No. 1, e014215, 01.01.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between soil heavy metals and fatty liver disease in men in Taiwan

T2 - A cross sectional study

AU - Lin, Yen Chih

AU - Lian, Ie Bin

AU - Kor, Chew Teng

AU - Chang, Chia Chu

AU - Su, Pei Yuan

AU - Chang, Wan Tzu

AU - Liang, Yu Fen

AU - Su, Wei Wen

AU - Soon, Maw Soan

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N2 - Objectives: Metabolic factors are major risk factors for non-alcoholic fatty liver disease although other factors may also contribute to development of fatty liver disease. We explored the association between exposure to soil heavy metals and prevalence of fatty liver disease. Methods: We retrospectively analysed data from patients diagnosed with fatty liver disease in 2014 at the Health Evaluation Centre of Chang-Hua Christian Hospital (n=1137). We used residency data provided in the records of the Health Evaluation Centre and data for soil metal concentrations from a nationwide survey conducted by the Environmental Protection Administration of Taiwan. We studied the correlations between the severity of fatty liver disease and concentrations of soil heavy metals (arsenic, mercury, cadmium, chromium, copper, nickel, lead and zinc). Results: The prevalence of moderate to severe fatty liver disease in our study was 26.5%. Using univariate and multivariate analysis, we demonstrated that the presence of soil heavy metals was a significant risk factor for fatty liver disease in men (OR 1.83, 95% CI 1.161 to 2.899, p=0.009). With stratification by body mass index (BMI) and gender, lean men with a BMI <24 kg/m2 were the most susceptible to soil heavy metals (OR 5.059, 95% CI 1.628 to 15.728, p<0.05). Conclusions: Our study suggested a significant association between exposure to soil heavy metals and fatty liver disease in lean men.

AB - Objectives: Metabolic factors are major risk factors for non-alcoholic fatty liver disease although other factors may also contribute to development of fatty liver disease. We explored the association between exposure to soil heavy metals and prevalence of fatty liver disease. Methods: We retrospectively analysed data from patients diagnosed with fatty liver disease in 2014 at the Health Evaluation Centre of Chang-Hua Christian Hospital (n=1137). We used residency data provided in the records of the Health Evaluation Centre and data for soil metal concentrations from a nationwide survey conducted by the Environmental Protection Administration of Taiwan. We studied the correlations between the severity of fatty liver disease and concentrations of soil heavy metals (arsenic, mercury, cadmium, chromium, copper, nickel, lead and zinc). Results: The prevalence of moderate to severe fatty liver disease in our study was 26.5%. Using univariate and multivariate analysis, we demonstrated that the presence of soil heavy metals was a significant risk factor for fatty liver disease in men (OR 1.83, 95% CI 1.161 to 2.899, p=0.009). With stratification by body mass index (BMI) and gender, lean men with a BMI <24 kg/m2 were the most susceptible to soil heavy metals (OR 5.059, 95% CI 1.628 to 15.728, p<0.05). Conclusions: Our study suggested a significant association between exposure to soil heavy metals and fatty liver disease in lean men.

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