Age-accelerated psychomotor slowing in temporal lobe epilepsy

Connie Sung, Jana E. Jones, Daren C. Jackson, Yui Chung Chan, Fong Chan, Michael Seidenberg, Bruce P. Hermann

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cognitive and psychomotor slowing is a complication of epilepsy and is less often a focus of investigation relative to other cognitive domains (e.g., memory). A diversity of tasks has been used to examine psychomotor slowing in epilepsy, but it remains unknown whether the degree of epilepsy-related slowing is fixed or is exacerbated with increasing task demand. Also unknown is to what degree age related slowing is accelerated in epilepsy. Participants with temporal lobe epilepsy (n=50) were compared to healthy controls (n=69) across three tasks of psychomotor speed with varied complexity. Performance was examined as a function of group (epilepsy, controls), task complexity (simple, intermediate, complex), and chronological age. The results showed that speed of performance declined across the epilepsy and control participants as a function of task complexity. Epilepsy participants were significantly slower than controls across the three tasks, and there was a significant three-way interaction (group by task complexity by age). These results demonstrate that psychomotor slowing is related to task complexity in both epilepsy and healthy control participants, always greater in epilepsy participants, and there is a significant age acceleration of psychomotor slowing in the epilepsy group that is magnified by complex tasks.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalEpilepsy Research
Volume103
Issue number2-3
DOIs
Publication statusPublished - 2013 Feb 1

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Temporal Lobe Epilepsy
Epilepsy
Healthy Volunteers
Control Groups

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Sung, C., Jones, J. E., Jackson, D. C., Chan, Y. C., Chan, F., Seidenberg, M., & Hermann, B. P. (2013). Age-accelerated psychomotor slowing in temporal lobe epilepsy. Epilepsy Research, 103(2-3), 231-236. https://doi.org/10.1016/j.eplepsyres.2012.08.011
Sung, Connie ; Jones, Jana E. ; Jackson, Daren C. ; Chan, Yui Chung ; Chan, Fong ; Seidenberg, Michael ; Hermann, Bruce P. / Age-accelerated psychomotor slowing in temporal lobe epilepsy. In: Epilepsy Research. 2013 ; Vol. 103, No. 2-3. pp. 231-236.
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Sung, C, Jones, JE, Jackson, DC, Chan, YC, Chan, F, Seidenberg, M & Hermann, BP 2013, 'Age-accelerated psychomotor slowing in temporal lobe epilepsy', Epilepsy Research, vol. 103, no. 2-3, pp. 231-236. https://doi.org/10.1016/j.eplepsyres.2012.08.011

Age-accelerated psychomotor slowing in temporal lobe epilepsy. / Sung, Connie; Jones, Jana E.; Jackson, Daren C.; Chan, Yui Chung; Chan, Fong; Seidenberg, Michael; Hermann, Bruce P.

In: Epilepsy Research, Vol. 103, No. 2-3, 01.02.2013, p. 231-236.

Research output: Contribution to journalArticle

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Sung C, Jones JE, Jackson DC, Chan YC, Chan F, Seidenberg M et al. Age-accelerated psychomotor slowing in temporal lobe epilepsy. Epilepsy Research. 2013 Feb 1;103(2-3):231-236. https://doi.org/10.1016/j.eplepsyres.2012.08.011