Abstract
Cognitive and psychomotor slowing is a complication of epilepsy and is less often a focus of investigation relative to other cognitive domains (e.g., memory). A diversity of tasks has been used to examine psychomotor slowing in epilepsy, but it remains unknown whether the degree of epilepsy-related slowing is fixed or is exacerbated with increasing task demand. Also unknown is to what degree age related slowing is accelerated in epilepsy. Participants with temporal lobe epilepsy (n=50) were compared to healthy controls (n=69) across three tasks of psychomotor speed with varied complexity. Performance was examined as a function of group (epilepsy, controls), task complexity (simple, intermediate, complex), and chronological age. The results showed that speed of performance declined across the epilepsy and control participants as a function of task complexity. Epilepsy participants were significantly slower than controls across the three tasks, and there was a significant three-way interaction (group by task complexity by age). These results demonstrate that psychomotor slowing is related to task complexity in both epilepsy and healthy control participants, always greater in epilepsy participants, and there is a significant age acceleration of psychomotor slowing in the epilepsy group that is magnified by complex tasks.
| Original language | English |
|---|---|
| Pages (from-to) | 231-236 |
| Number of pages | 6 |
| Journal | Epilepsy Research |
| Volume | 103 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 2013 Feb 1 |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
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Age-accelerated psychomotor slowing in temporal lobe epilepsy. / Sung, Connie; Jones, Jana E.; Jackson, Daren C.; Chan, Yui Chung; Chan, Fong; Seidenberg, Michael; Hermann, Bruce P.
In: Epilepsy Research, Vol. 103, No. 2-3, 01.02.2013, p. 231-236.Research output: Contribution to journal › Article
TY - JOUR
T1 - Age-accelerated psychomotor slowing in temporal lobe epilepsy
AU - Sung, Connie
AU - Jones, Jana E.
AU - Jackson, Daren C.
AU - Chan, Yui Chung
AU - Chan, Fong
AU - Seidenberg, Michael
AU - Hermann, Bruce P.
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Cognitive and psychomotor slowing is a complication of epilepsy and is less often a focus of investigation relative to other cognitive domains (e.g., memory). A diversity of tasks has been used to examine psychomotor slowing in epilepsy, but it remains unknown whether the degree of epilepsy-related slowing is fixed or is exacerbated with increasing task demand. Also unknown is to what degree age related slowing is accelerated in epilepsy. Participants with temporal lobe epilepsy (n=50) were compared to healthy controls (n=69) across three tasks of psychomotor speed with varied complexity. Performance was examined as a function of group (epilepsy, controls), task complexity (simple, intermediate, complex), and chronological age. The results showed that speed of performance declined across the epilepsy and control participants as a function of task complexity. Epilepsy participants were significantly slower than controls across the three tasks, and there was a significant three-way interaction (group by task complexity by age). These results demonstrate that psychomotor slowing is related to task complexity in both epilepsy and healthy control participants, always greater in epilepsy participants, and there is a significant age acceleration of psychomotor slowing in the epilepsy group that is magnified by complex tasks.
AB - Cognitive and psychomotor slowing is a complication of epilepsy and is less often a focus of investigation relative to other cognitive domains (e.g., memory). A diversity of tasks has been used to examine psychomotor slowing in epilepsy, but it remains unknown whether the degree of epilepsy-related slowing is fixed or is exacerbated with increasing task demand. Also unknown is to what degree age related slowing is accelerated in epilepsy. Participants with temporal lobe epilepsy (n=50) were compared to healthy controls (n=69) across three tasks of psychomotor speed with varied complexity. Performance was examined as a function of group (epilepsy, controls), task complexity (simple, intermediate, complex), and chronological age. The results showed that speed of performance declined across the epilepsy and control participants as a function of task complexity. Epilepsy participants were significantly slower than controls across the three tasks, and there was a significant three-way interaction (group by task complexity by age). These results demonstrate that psychomotor slowing is related to task complexity in both epilepsy and healthy control participants, always greater in epilepsy participants, and there is a significant age acceleration of psychomotor slowing in the epilepsy group that is magnified by complex tasks.
UR - http://www.scopus.com/inward/record.url?scp=84873099509&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873099509&partnerID=8YFLogxK
U2 - 10.1016/j.eplepsyres.2012.08.011
DO - 10.1016/j.eplepsyres.2012.08.011
M3 - Article
C2 - 22989854
AN - SCOPUS:84873099509
VL - 103
SP - 231
EP - 236
JO - Epilepsy Research
JF - Epilepsy Research
SN - 0920-1211
IS - 2-3
ER -