Adiponectin, inflammation, and the expression of the metabolic syndrome in obese individuals: The impact of rapid weight lose through caloric restriction

Antonios M. Xydakis, Christopher C. Case, Peter H. Jones, Ron C. Hoogeveen, Mine Yine Liu, E. O'Brian Smith, Kathleen W. Nelson, Christie M. Ballantyne

Research output: Contribution to journalArticle

232 Citations (Scopus)

Abstract

Severe obesity increases the prevalence of the metabolic syndrome, and moderate acute weight loss with a very low-calorie diet in obese subjects with the metabolic syndrome leads to significant metabolic benefits. Adiponectin has been implicated in both the pathogenesis of obesity-related insulin resistance and increased inflammation. We analyzed the relationship of the adipocyte-derived hormone adiponectin with indices of inflammation, adiposity, and insulin resistance in obese subjects with (MS+, n = 40) and without (MS-, n = 40) the metabolic syndrome and examined the acute effects of rapid weight loss. MS+ subjects had significantly lower adiponectin (7.6 ± 0.6 vs. 10.4 ± 0.6 μg/ml; P = 0.003) and significantly higher TNF-α (3.3 ± 0.2 vs. 2.8 ± 0.3 pg/ml; P = 0.004) levels compared with MS- subjects matched for age and body mass index. Plasma adiponectin and TNF-α levels were inversely related to the number of metabolic syndrome factors in a stepwise manner. After 4-6 wk of weight loss, there was marked improvement in glucose, insulin, leptin, and triglycerides, whereas adiponectin and TNF-α concentrations did not change. Thus, increases in plasma levels of adiponectin or reductions in TNF-α are not required for marked improvements in glucose/insulin and lipid metabolism with acute weight loss.

Original languageEnglish
Pages (from-to)2697-2703
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume89
Issue number6
DOIs
Publication statusPublished - 2004 Jun

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Adiponectin, inflammation, and the expression of the metabolic syndrome in obese individuals: The impact of rapid weight lose through caloric restriction'. Together they form a unique fingerprint.

  • Cite this