A population-based, case-control study of green tea consumption and leukemia risk in southwestern Taiwan

Yau Chang Kuo, Chu Ling Yu, Chen Yu Liu, Su-Fen Wang, Pi Chen Pan, Ming Tsang Wu, Chi Kung Ho, Yu Shing Lo, Yi Li, David C. Christiani, Tai Tsung Chang, Sheng Fung Lin, Shyh Shin Chiou, Ren Chin Jang, Hui Hua Hsiao, Ta Chih Liu, Pei Chin Lin, Chih Cheng Hsiao, Jiunn Ming Sheen, Ching Yuan KuoMing Chung Wang, Cheng Hua Huang, Chung Bin Huang, Shyh Jer Lin, Yu Ming Sun, Kai Sheng Hsieh, Yu Hsiang Chang, Yuk Cheung Wong, Hung Bo Wu

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: This study investigated the association between green tea consumption and leukemia. Methods: A total of 252 cases (90.3% response) and 637 controls (53.4% response) were enrolled. Controls were matched for cases on age and gender. Information was collected on participants' living habits, including tea consumption. Green tea was used as a standard to estimate the total amount of individual catechin consumption. We stratified individual consumption of catechins into four levels. Conditional logistic regression models were fit to subjects aged 0-15 and 16-29 years to evaluate separate associations between leukemia and catechin consumption. Results: A significant inverse association between green tea consumption and leukemia risk was found in individuals aged 16-29 years, whereas no significant association was found in the younger age groups. For the older group with higher amounts of tea consumption (>550 units of catechins), the adjusted odds ratio (OR) compared with the group without tea consumption was 0.47 [95% confidence interval (CI) = 0.23-0.97]. After we adjusted for smoking status and medical irradiation exposure, the overall OR for all participants was 0.49 (95% CI = 0.27-0.91), indicating an inverse relation between large amounts of catechins and leukemia. Conclusion: Drinking sufficient amounts of tea, especially green tea, which contains more catechins than oolong tea and black tea, may reduce the risk of leukemia.

Original languageEnglish
Pages (from-to)57-65
Number of pages9
JournalCancer Causes and Control
Volume20
Issue number1
DOIs
Publication statusPublished - 2009 Feb 1

Fingerprint

Tea
Taiwan
Case-Control Studies
Leukemia
Catechin
Population
Logistic Models
Odds Ratio
Confidence Intervals
Drinking
Habits
Age Groups
Smoking

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kuo, Yau Chang ; Yu, Chu Ling ; Liu, Chen Yu ; Wang, Su-Fen ; Pan, Pi Chen ; Wu, Ming Tsang ; Ho, Chi Kung ; Lo, Yu Shing ; Li, Yi ; Christiani, David C. ; Chang, Tai Tsung ; Lin, Sheng Fung ; Chiou, Shyh Shin ; Jang, Ren Chin ; Hsiao, Hui Hua ; Liu, Ta Chih ; Lin, Pei Chin ; Hsiao, Chih Cheng ; Sheen, Jiunn Ming ; Kuo, Ching Yuan ; Wang, Ming Chung ; Huang, Cheng Hua ; Huang, Chung Bin ; Lin, Shyh Jer ; Sun, Yu Ming ; Hsieh, Kai Sheng ; Chang, Yu Hsiang ; Wong, Yuk Cheung ; Wu, Hung Bo. / A population-based, case-control study of green tea consumption and leukemia risk in southwestern Taiwan. In: Cancer Causes and Control. 2009 ; Vol. 20, No. 1. pp. 57-65.
@article{3a95853d8e3d441ea521d4e1fa0480ca,
title = "A population-based, case-control study of green tea consumption and leukemia risk in southwestern Taiwan",
abstract = "Objective: This study investigated the association between green tea consumption and leukemia. Methods: A total of 252 cases (90.3{\%} response) and 637 controls (53.4{\%} response) were enrolled. Controls were matched for cases on age and gender. Information was collected on participants' living habits, including tea consumption. Green tea was used as a standard to estimate the total amount of individual catechin consumption. We stratified individual consumption of catechins into four levels. Conditional logistic regression models were fit to subjects aged 0-15 and 16-29 years to evaluate separate associations between leukemia and catechin consumption. Results: A significant inverse association between green tea consumption and leukemia risk was found in individuals aged 16-29 years, whereas no significant association was found in the younger age groups. For the older group with higher amounts of tea consumption (>550 units of catechins), the adjusted odds ratio (OR) compared with the group without tea consumption was 0.47 [95{\%} confidence interval (CI) = 0.23-0.97]. After we adjusted for smoking status and medical irradiation exposure, the overall OR for all participants was 0.49 (95{\%} CI = 0.27-0.91), indicating an inverse relation between large amounts of catechins and leukemia. Conclusion: Drinking sufficient amounts of tea, especially green tea, which contains more catechins than oolong tea and black tea, may reduce the risk of leukemia.",
author = "Kuo, {Yau Chang} and Yu, {Chu Ling} and Liu, {Chen Yu} and Su-Fen Wang and Pan, {Pi Chen} and Wu, {Ming Tsang} and Ho, {Chi Kung} and Lo, {Yu Shing} and Yi Li and Christiani, {David C.} and Chang, {Tai Tsung} and Lin, {Sheng Fung} and Chiou, {Shyh Shin} and Jang, {Ren Chin} and Hsiao, {Hui Hua} and Liu, {Ta Chih} and Lin, {Pei Chin} and Hsiao, {Chih Cheng} and Sheen, {Jiunn Ming} and Kuo, {Ching Yuan} and Wang, {Ming Chung} and Huang, {Cheng Hua} and Huang, {Chung Bin} and Lin, {Shyh Jer} and Sun, {Yu Ming} and Hsieh, {Kai Sheng} and Chang, {Yu Hsiang} and Wong, {Yuk Cheung} and Wu, {Hung Bo}",
year = "2009",
month = "2",
day = "1",
doi = "10.1007/s10552-008-9217-7",
language = "English",
volume = "20",
pages = "57--65",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "1",

}

Kuo, YC, Yu, CL, Liu, CY, Wang, S-F, Pan, PC, Wu, MT, Ho, CK, Lo, YS, Li, Y, Christiani, DC, Chang, TT, Lin, SF, Chiou, SS, Jang, RC, Hsiao, HH, Liu, TC, Lin, PC, Hsiao, CC, Sheen, JM, Kuo, CY, Wang, MC, Huang, CH, Huang, CB, Lin, SJ, Sun, YM, Hsieh, KS, Chang, YH, Wong, YC & Wu, HB 2009, 'A population-based, case-control study of green tea consumption and leukemia risk in southwestern Taiwan', Cancer Causes and Control, vol. 20, no. 1, pp. 57-65. https://doi.org/10.1007/s10552-008-9217-7

A population-based, case-control study of green tea consumption and leukemia risk in southwestern Taiwan. / Kuo, Yau Chang; Yu, Chu Ling; Liu, Chen Yu; Wang, Su-Fen; Pan, Pi Chen; Wu, Ming Tsang; Ho, Chi Kung; Lo, Yu Shing; Li, Yi; Christiani, David C.; Chang, Tai Tsung; Lin, Sheng Fung; Chiou, Shyh Shin; Jang, Ren Chin; Hsiao, Hui Hua; Liu, Ta Chih; Lin, Pei Chin; Hsiao, Chih Cheng; Sheen, Jiunn Ming; Kuo, Ching Yuan; Wang, Ming Chung; Huang, Cheng Hua; Huang, Chung Bin; Lin, Shyh Jer; Sun, Yu Ming; Hsieh, Kai Sheng; Chang, Yu Hsiang; Wong, Yuk Cheung; Wu, Hung Bo.

In: Cancer Causes and Control, Vol. 20, No. 1, 01.02.2009, p. 57-65.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A population-based, case-control study of green tea consumption and leukemia risk in southwestern Taiwan

AU - Kuo, Yau Chang

AU - Yu, Chu Ling

AU - Liu, Chen Yu

AU - Wang, Su-Fen

AU - Pan, Pi Chen

AU - Wu, Ming Tsang

AU - Ho, Chi Kung

AU - Lo, Yu Shing

AU - Li, Yi

AU - Christiani, David C.

AU - Chang, Tai Tsung

AU - Lin, Sheng Fung

AU - Chiou, Shyh Shin

AU - Jang, Ren Chin

AU - Hsiao, Hui Hua

AU - Liu, Ta Chih

AU - Lin, Pei Chin

AU - Hsiao, Chih Cheng

AU - Sheen, Jiunn Ming

AU - Kuo, Ching Yuan

AU - Wang, Ming Chung

AU - Huang, Cheng Hua

AU - Huang, Chung Bin

AU - Lin, Shyh Jer

AU - Sun, Yu Ming

AU - Hsieh, Kai Sheng

AU - Chang, Yu Hsiang

AU - Wong, Yuk Cheung

AU - Wu, Hung Bo

PY - 2009/2/1

Y1 - 2009/2/1

N2 - Objective: This study investigated the association between green tea consumption and leukemia. Methods: A total of 252 cases (90.3% response) and 637 controls (53.4% response) were enrolled. Controls were matched for cases on age and gender. Information was collected on participants' living habits, including tea consumption. Green tea was used as a standard to estimate the total amount of individual catechin consumption. We stratified individual consumption of catechins into four levels. Conditional logistic regression models were fit to subjects aged 0-15 and 16-29 years to evaluate separate associations between leukemia and catechin consumption. Results: A significant inverse association between green tea consumption and leukemia risk was found in individuals aged 16-29 years, whereas no significant association was found in the younger age groups. For the older group with higher amounts of tea consumption (>550 units of catechins), the adjusted odds ratio (OR) compared with the group without tea consumption was 0.47 [95% confidence interval (CI) = 0.23-0.97]. After we adjusted for smoking status and medical irradiation exposure, the overall OR for all participants was 0.49 (95% CI = 0.27-0.91), indicating an inverse relation between large amounts of catechins and leukemia. Conclusion: Drinking sufficient amounts of tea, especially green tea, which contains more catechins than oolong tea and black tea, may reduce the risk of leukemia.

AB - Objective: This study investigated the association between green tea consumption and leukemia. Methods: A total of 252 cases (90.3% response) and 637 controls (53.4% response) were enrolled. Controls were matched for cases on age and gender. Information was collected on participants' living habits, including tea consumption. Green tea was used as a standard to estimate the total amount of individual catechin consumption. We stratified individual consumption of catechins into four levels. Conditional logistic regression models were fit to subjects aged 0-15 and 16-29 years to evaluate separate associations between leukemia and catechin consumption. Results: A significant inverse association between green tea consumption and leukemia risk was found in individuals aged 16-29 years, whereas no significant association was found in the younger age groups. For the older group with higher amounts of tea consumption (>550 units of catechins), the adjusted odds ratio (OR) compared with the group without tea consumption was 0.47 [95% confidence interval (CI) = 0.23-0.97]. After we adjusted for smoking status and medical irradiation exposure, the overall OR for all participants was 0.49 (95% CI = 0.27-0.91), indicating an inverse relation between large amounts of catechins and leukemia. Conclusion: Drinking sufficient amounts of tea, especially green tea, which contains more catechins than oolong tea and black tea, may reduce the risk of leukemia.

UR - http://www.scopus.com/inward/record.url?scp=58249113014&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58249113014&partnerID=8YFLogxK

U2 - 10.1007/s10552-008-9217-7

DO - 10.1007/s10552-008-9217-7

M3 - Article

C2 - 18752033

AN - SCOPUS:58249113014

VL - 20

SP - 57

EP - 65

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 1

ER -