A mild and general method for preparation of α-glycosyl chlorides

Chih Wei Chang, Shih Sheng Chang, Chin Sheng Chao, Kwok Kong T. Mong

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21 Citations (Scopus)

Abstract

A mild and efficient chlorination method for production of glycosyl chlorides is first described which employs inexpensive trichlorotriazine (TCT) and DMF as a chlorination reagent and is compatible with typical acid-labile hydroxyl protecting functions. The scope and limitations, reaction mechanism and its application in the sequential glycosylations are discussed.

Original languageEnglish
Pages (from-to)4536-4540
Number of pages5
JournalTetrahedron Letters
Volume50
Issue number31
DOIs
Publication statusPublished - 2009 Aug 5

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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