A method for the regioselective synthesis of 1-alkyl-1H-indazoles

Han Jun Liu, Shiang Fu Hung, Chuan Lin Chen, Mei Huey Lin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A method for the regioselective synthesis of 3-unsubstituted 1-alkyl-1H-indazoles, starting with 2-halobenzonitriles and N-alkylhydrazines, is described. The two-step reaction pathway proceeds through the intermediacy of 1-alkyl-3-amino-1H-indazoles followed by reductive deamination.

Original languageEnglish
Pages (from-to)3907-3912
Number of pages6
JournalTetrahedron
Volume69
Issue number19
DOIs
Publication statusPublished - 2013 May 13

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Indazoles
Deamination

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Liu, Han Jun ; Hung, Shiang Fu ; Chen, Chuan Lin ; Lin, Mei Huey. / A method for the regioselective synthesis of 1-alkyl-1H-indazoles. In: Tetrahedron. 2013 ; Vol. 69, No. 19. pp. 3907-3912.
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A method for the regioselective synthesis of 1-alkyl-1H-indazoles. / Liu, Han Jun; Hung, Shiang Fu; Chen, Chuan Lin; Lin, Mei Huey.

In: Tetrahedron, Vol. 69, No. 19, 13.05.2013, p. 3907-3912.

Research output: Contribution to journalArticle

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AU - Hung, Shiang Fu

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AU - Lin, Mei Huey

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