A dipole-assisted solid-phase extraction microchip combined with inductively coupled plasma-mass spectrometry for online determination of trace heavy metals in natural water

Tsung Ting Shih, I. Hsiang Hsu, Shun Niang Chen, Ping Hung Chen, Ming Jay Deng, Yu Chen, Yang Wei Lin, Yuh Chang Sun

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We employed a polymeric material, poly(methyl methacrylate) (PMMA), for fabricating a microdevice and then implanted the chlorine (Cl)-containing solid-phase extraction (SPE) functionality into the PMMA chip to develop an innovative on-chip dipole-assisted SPE technique. Instead of the ion-ion interactions utilized in on-chip SPE techniques, the dipole-ion interactions between the highly electronegative C-Cl moieties in the channel interior and the positively charged metal ions were employed to facilitate the on-chip SPE procedures. Furthermore, to avoid labor-intensive manual manipulation, a programmable valve manifold was designed as an interface combining the dipole-assisted SPE microchip and inductively coupled plasma-mass spectrometry (ICP-MS) to achieve the fully automated operation. Under the optimized operation conditions for the established system, the detection limits for each analyte ion were obtained based on three times the standard deviation of seven measurements of the blank eluent solution. The limits ranged from 3.48 to 20.68 ng L-1, suggesting that this technique appears uniquely suited for determining the levels of heavy metal ions in natural water. Indeed, a series of validation procedures demonstrated that the developed method could be satisfactorily applied to the determination of trace heavy metals in natural water. Remarkably, the developed device was durable enough to be reused more than 160 times without any loss in its analytical performance. To the best of our knowledge, this is the first study reporting on the combination of a dipole-assisted SPE microchip and elemental analysis instrument for the online determination of trace heavy metal ions.

Original languageEnglish
Pages (from-to)600-608
Number of pages9
JournalAnalyst
Volume140
Issue number2
DOIs
Publication statusPublished - 2015 Jan 21

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Inductively coupled plasma mass spectrometry
Solid Phase Extraction
Heavy Metals
Heavy metals
trace metal
Mass Spectrometry
mass spectrometry
heavy metal
plasma
Ions
ion
Water
Metal ions
Heavy Ions
Chlorine
Polymethyl Methacrylate
Polymethyl methacrylates
Heavy ions
water
Microchip Analytical Procedures

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

Cite this

Shih, Tsung Ting ; Hsu, I. Hsiang ; Chen, Shun Niang ; Chen, Ping Hung ; Deng, Ming Jay ; Chen, Yu ; Lin, Yang Wei ; Sun, Yuh Chang. / A dipole-assisted solid-phase extraction microchip combined with inductively coupled plasma-mass spectrometry for online determination of trace heavy metals in natural water. In: Analyst. 2015 ; Vol. 140, No. 2. pp. 600-608.
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A dipole-assisted solid-phase extraction microchip combined with inductively coupled plasma-mass spectrometry for online determination of trace heavy metals in natural water. / Shih, Tsung Ting; Hsu, I. Hsiang; Chen, Shun Niang; Chen, Ping Hung; Deng, Ming Jay; Chen, Yu; Lin, Yang Wei; Sun, Yuh Chang.

In: Analyst, Vol. 140, No. 2, 21.01.2015, p. 600-608.

Research output: Contribution to journalArticle

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AU - Shih, Tsung Ting

AU - Hsu, I. Hsiang

AU - Chen, Shun Niang

AU - Chen, Ping Hung

AU - Deng, Ming Jay

AU - Chen, Yu

AU - Lin, Yang Wei

AU - Sun, Yuh Chang

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