A density functional theory study for the role of end groups on the antioxidative potency of carotenoids

Fu Xing Liao, Ching-Han Hu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Role of carotenoid end groups on their chainbreaking potency against lipid peroxidation was explored using density functional theory. Hydrogen abstraction and addition of the peroxide and O2 of the resultant radicals were investigated. The protective potency of CARs is exhibited by their faster reactions with the peroxide radical than fatty acid, and by the much reduced reactivity of the initiated radical toward O2. 3,3'-Dihydroxyisorenieratene (DHIR), which consists of hydroxyaryl (3-hydroxy-φ) end groups, is by far the most efficient chain-breaking antioxidant. The quinone form of DHIR is also an effective antioxidant. 4-Oxo functional group in β-ring enhances the antioxidative potency of carotenoids, while 3-hydroxyl functional group in β-ring does not have a noticeable effect.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalTheoretical Chemistry Accounts
Volume132
Issue number5
DOIs
Publication statusPublished - 2013 Mar 22

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carotenoids
Peroxides
Carotenoids
Functional groups
Density functional theory
Antioxidants
density functional theory
antioxidants
peroxides
Hydroxyl Radical
Hydrogen
Fatty Acids
Lipids
rings
quinones
fatty acids
lipids
reactivity
hydrogen
3,3'-dihydroxyisorenieratene

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry

Cite this

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abstract = "Role of carotenoid end groups on their chainbreaking potency against lipid peroxidation was explored using density functional theory. Hydrogen abstraction and addition of the peroxide and O2 of the resultant radicals were investigated. The protective potency of CARs is exhibited by their faster reactions with the peroxide radical than fatty acid, and by the much reduced reactivity of the initiated radical toward O2. 3,3'-Dihydroxyisorenieratene (DHIR), which consists of hydroxyaryl (3-hydroxy-φ) end groups, is by far the most efficient chain-breaking antioxidant. The quinone form of DHIR is also an effective antioxidant. 4-Oxo functional group in β-ring enhances the antioxidative potency of carotenoids, while 3-hydroxyl functional group in β-ring does not have a noticeable effect.",
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A density functional theory study for the role of end groups on the antioxidative potency of carotenoids. / Liao, Fu Xing; Hu, Ching-Han.

In: Theoretical Chemistry Accounts, Vol. 132, No. 5, 22.03.2013, p. 1-13.

Research output: Contribution to journalArticle

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