A cut-off of daily sedentary time and all-cause mortality in adults

A meta-regression analysis involving more than 1 million participants

Po-Wen Ku, Andrew Steptoe, Yung Liao, Ming Chun Hsueh, Li Jung Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The appropriate limit to the amount of daily sedentary time (ST) required to minimize mortality is uncertain. This meta-analysis aimed to quantify the dose-response association between daily ST and all-cause mortality and to explore the cut-off point above which health is impaired in adults aged 18-64 years old. We also examined whether there are differences between studies using self-report ST and those with device-based ST. Methods: Prospective cohort studies providing effect estimates of daily ST (exposure) on all-cause mortality (outcome) were identified via MEDLINE, PubMed, Scopus, Web of Science, and Google Scholar databases until January 2018. Dose-response relationships between daily ST and all-cause mortality were examined using random-effects meta-regression models. Results: Based on the pooled data for more than 1 million participants from 19 studies, the results showed a log-linear dose-response association between daily ST and all-cause mortality. Overall, more time spent in sedentary behaviors is associated with increased mortality risks. However, the method of measuring ST moderated the association between daily ST and mortality risk (p<0.05). The cut-off of daily ST in studies with self-report ST was 7 h/day in comparison with 9 h/day for those with device-based ST. Conclusions: Higher amounts of daily ST are log-linearly associated with increased risk of all-cause mortality in adults. On the basis of a limited number of studies using device-based measures, the findings suggest that it may be appropriate to encourage adults to engage in less sedentary behaviors, with fewer than 9 h a day being relevant for all-cause mortality.

Original languageEnglish
Article number74
JournalBMC Medicine
Volume16
Issue number1
DOIs
Publication statusPublished - 2018 May 25

Fingerprint

Meta-Analysis
Regression Analysis
Mortality
Equipment and Supplies
Self Report
PubMed
MEDLINE
Cohort Studies
Databases
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{097e11e95a594dd29e38409d621f67a3,
title = "A cut-off of daily sedentary time and all-cause mortality in adults: A meta-regression analysis involving more than 1 million participants",
abstract = "Background: The appropriate limit to the amount of daily sedentary time (ST) required to minimize mortality is uncertain. This meta-analysis aimed to quantify the dose-response association between daily ST and all-cause mortality and to explore the cut-off point above which health is impaired in adults aged 18-64 years old. We also examined whether there are differences between studies using self-report ST and those with device-based ST. Methods: Prospective cohort studies providing effect estimates of daily ST (exposure) on all-cause mortality (outcome) were identified via MEDLINE, PubMed, Scopus, Web of Science, and Google Scholar databases until January 2018. Dose-response relationships between daily ST and all-cause mortality were examined using random-effects meta-regression models. Results: Based on the pooled data for more than 1 million participants from 19 studies, the results showed a log-linear dose-response association between daily ST and all-cause mortality. Overall, more time spent in sedentary behaviors is associated with increased mortality risks. However, the method of measuring ST moderated the association between daily ST and mortality risk (p<0.05). The cut-off of daily ST in studies with self-report ST was 7 h/day in comparison with 9 h/day for those with device-based ST. Conclusions: Higher amounts of daily ST are log-linearly associated with increased risk of all-cause mortality in adults. On the basis of a limited number of studies using device-based measures, the findings suggest that it may be appropriate to encourage adults to engage in less sedentary behaviors, with fewer than 9 h a day being relevant for all-cause mortality.",
author = "Po-Wen Ku and Andrew Steptoe and Yung Liao and Hsueh, {Ming Chun} and Chen, {Li Jung}",
year = "2018",
month = "5",
day = "25",
doi = "10.1186/s12916-018-1062-2",
language = "English",
volume = "16",
journal = "BMC Medicine",
issn = "1741-7015",
publisher = "BioMed Central",
number = "1",

}

A cut-off of daily sedentary time and all-cause mortality in adults : A meta-regression analysis involving more than 1 million participants. / Ku, Po-Wen; Steptoe, Andrew; Liao, Yung; Hsueh, Ming Chun; Chen, Li Jung.

In: BMC Medicine, Vol. 16, No. 1, 74, 25.05.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A cut-off of daily sedentary time and all-cause mortality in adults

T2 - A meta-regression analysis involving more than 1 million participants

AU - Ku, Po-Wen

AU - Steptoe, Andrew

AU - Liao, Yung

AU - Hsueh, Ming Chun

AU - Chen, Li Jung

PY - 2018/5/25

Y1 - 2018/5/25

N2 - Background: The appropriate limit to the amount of daily sedentary time (ST) required to minimize mortality is uncertain. This meta-analysis aimed to quantify the dose-response association between daily ST and all-cause mortality and to explore the cut-off point above which health is impaired in adults aged 18-64 years old. We also examined whether there are differences between studies using self-report ST and those with device-based ST. Methods: Prospective cohort studies providing effect estimates of daily ST (exposure) on all-cause mortality (outcome) were identified via MEDLINE, PubMed, Scopus, Web of Science, and Google Scholar databases until January 2018. Dose-response relationships between daily ST and all-cause mortality were examined using random-effects meta-regression models. Results: Based on the pooled data for more than 1 million participants from 19 studies, the results showed a log-linear dose-response association between daily ST and all-cause mortality. Overall, more time spent in sedentary behaviors is associated with increased mortality risks. However, the method of measuring ST moderated the association between daily ST and mortality risk (p<0.05). The cut-off of daily ST in studies with self-report ST was 7 h/day in comparison with 9 h/day for those with device-based ST. Conclusions: Higher amounts of daily ST are log-linearly associated with increased risk of all-cause mortality in adults. On the basis of a limited number of studies using device-based measures, the findings suggest that it may be appropriate to encourage adults to engage in less sedentary behaviors, with fewer than 9 h a day being relevant for all-cause mortality.

AB - Background: The appropriate limit to the amount of daily sedentary time (ST) required to minimize mortality is uncertain. This meta-analysis aimed to quantify the dose-response association between daily ST and all-cause mortality and to explore the cut-off point above which health is impaired in adults aged 18-64 years old. We also examined whether there are differences between studies using self-report ST and those with device-based ST. Methods: Prospective cohort studies providing effect estimates of daily ST (exposure) on all-cause mortality (outcome) were identified via MEDLINE, PubMed, Scopus, Web of Science, and Google Scholar databases until January 2018. Dose-response relationships between daily ST and all-cause mortality were examined using random-effects meta-regression models. Results: Based on the pooled data for more than 1 million participants from 19 studies, the results showed a log-linear dose-response association between daily ST and all-cause mortality. Overall, more time spent in sedentary behaviors is associated with increased mortality risks. However, the method of measuring ST moderated the association between daily ST and mortality risk (p<0.05). The cut-off of daily ST in studies with self-report ST was 7 h/day in comparison with 9 h/day for those with device-based ST. Conclusions: Higher amounts of daily ST are log-linearly associated with increased risk of all-cause mortality in adults. On the basis of a limited number of studies using device-based measures, the findings suggest that it may be appropriate to encourage adults to engage in less sedentary behaviors, with fewer than 9 h a day being relevant for all-cause mortality.

UR - http://www.scopus.com/inward/record.url?scp=85047550138&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047550138&partnerID=8YFLogxK

U2 - 10.1186/s12916-018-1062-2

DO - 10.1186/s12916-018-1062-2

M3 - Article

VL - 16

JO - BMC Medicine

JF - BMC Medicine

SN - 1741-7015

IS - 1

M1 - 74

ER -