A batch fuzzy query system for predicting protein stability changes

Chao-Chin Wu, Liang Tsung Huang, Lien-Fu Lai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Predicting protein mutant stability changes is important for protein design. Although many methods have tried to improve prediction accuracy by various models, it will be difficult to employ them when the required input information is incomplete. Therefore, we have proposed a fuzzy query method previously to predict stability changes upon single mutations using partial input information. However, when a researcher has tens or hundreds of queries to predict, he needs to input query data repeatedly. It is better to issue queries in a batch, which incurs another problem. Because our proposed fuzzy query method is implemented in the FuzzyCLIPS language, it takes a long time to process a batch of queries. To shorten the response time, we propose parallelizing queries in emerging cluster systems or grid systems. Furthermore, to address the problem of heterogeneous computing power of cluster and grid nodes, a variety of self-scheduling schemes have been implemented for better load balance. Experimental results show that our proposed parallel fuzzy query system can provide hundreds of predications in more reasonable response time.

Original languageEnglish
Title of host publication2010 2nd International Conference on Computer Engineering and Applications, ICCEA 2010
Pages257-261
Number of pages5
Volume1
DOIs
Publication statusPublished - 2010 May 28
Event2nd International Conference on Computer Engineering and Applications, ICCEA 2010 - , Indonesia
Duration: 2010 Mar 192010 Mar 21

Other

Other2nd International Conference on Computer Engineering and Applications, ICCEA 2010
CountryIndonesia
Period10-03-1910-03-21

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Software

Cite this

Wu, C-C., Huang, L. T., & Lai, L-F. (2010). A batch fuzzy query system for predicting protein stability changes. In 2010 2nd International Conference on Computer Engineering and Applications, ICCEA 2010 (Vol. 1, pp. 257-261). [5445828] https://doi.org/10.1109/ICCEA.2010.58