Nai-Wan Hsiao

Associate Professor

  • 688 Citations
  • 13 h-Index
20032016
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Research Output 2003 2016

  • 688 Citations
  • 13 h-Index
  • 27 Article
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Article
2016
3 Citations (Scopus)

Comparative study between 3D-QSAR and Docking-Based Pharmacophore models for potent Plasomodium falciparum dihydroorotate dehydrogenase inhibitors

Tseng, T. S., Lee, Y. C., Hsiao, N. W., Liu, Y. R. & Tsai, K. C., 2016 Jan 15, In : Bioorganic and Medicinal Chemistry Letters. 26, 2, p. 265-271 7 p.

Research output: Contribution to journalArticle

Quantitative Structure-Activity Relationship
Plasmodium falciparum
Malaria
Parasites
Parasitic Diseases
1 Citation (Scopus)

Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

Tseng, T. S., Chuang, S. M., Hsiao, N. W., Chen, Y. W., Lee, Y. C., Lin, C. C., Huang, C. & Tsai, K. C., 2016 Jan 1, In : Molecular BioSystems. 12, 8, p. 2541-2551 11 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2 Inhibitors
Anti-Inflammatory Agents
Molecular Docking Simulation
Non-Steroidal Anti-Inflammatory Agents
Prostaglandin-Endoperoxide Synthases
2015
68 Citations (Scopus)

Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in vivo assay and computational molecular modeling

Chen, W. C., Tseng, T. S., Hsiao, N. W., Lin, Y. L., Wen, Z. H., Tsai, C. C., Lee, Y. C., Lin, H. H. & Tsai, K. C., 2015, In : Scientific Reports. 5, 7995.

Research output: Contribution to journalArticle

Monophenol Monooxygenase
Melanins
Zebrafish
Gastrodia
Agaricales
7 Citations (Scopus)

Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation

Tseng, T. S., Tsai, K. C., Chen, W. C., Wang, Y. T., Lee, Y. C., Lu, C. K., Don, M. J., Chang, C. Y., Lee, C. H., Lin, H. H., Hsu, H. J. & Hsiao, N. W., 2015 Jul 15, In : Journal of Agricultural and Food Chemistry. 63, 27, p. 6181-6188 8 p.

Research output: Contribution to journalArticle

dipeptides
Monophenol Monooxygenase
Dipeptides
Cysteine
cysteine
11 Citations (Scopus)

Phage display - Mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom

Lee, Y. C., Hsiao, N. W., Tseng, T. S., Chen, W. C., Lin, H. H., Leu, S. J., Yang, E. W. & Tsai, K. C., 2015 Jan 1, In : Molecular Pharmacology. 87, 2, p. 218-230 13 p., A8.

Research output: Contribution to journalArticle

Monophenol Monooxygenase
Sulfur
Bacteriophages
Cysteine
Agaricales
2014
171 Citations (Scopus)

Antiviral treatment for hepatitis C virus infection is associated with improved renal and cardiovascular outcomes in diabetic patients

Hsu, Y. C., Lin, J. T., Ho, H. J., Kao, Y. H., Huang, Y. T., Hsiao, N. W., Wu, M. S., Liu, Y. Y. & Wu, C. Y., 2014 Apr, In : Hepatology. 59, 4, p. 1293-1302 10 p.

Research output: Contribution to journalArticle

Virus Diseases
Hepacivirus
Antiviral Agents
Confidence Intervals
Kidney

Development of 3D-QSAR combination approach for discovering and analysing neuraminidase inhibitors in silico

Lin, C. Y., Chi, H. C., Shih, K. C., Zhou, J., Hsiao, N. W. & Tang, C. Y., 2014, In : International Journal of Data Mining and Bioinformatics. 9, 3, p. 305-320 16 p.

Research output: Contribution to journalArticle

activity structure
Quantitative Structure-Activity Relationship
Neuraminidase
Computer Simulation
Zanamivir
32 Citations (Scopus)

Purification and characterization of an aspartic protease from the Rhizopus Oryzae protease extract, peptidase R

Hsiao, N-W., Chen, Y., Kuan, Y. C., Lee, Y. C., Lee, S. K., Chan, H. H. & Kao, C. H., 2014 Jan 1, In : Electronic Journal of Biotechnology. 17, 2, p. 89-94 6 p.

Research output: Contribution to journalArticle

Rhizopus
Peptide Hydrolases
ethylenediamine
Enzymes
Chromatography
18 Citations (Scopus)

Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors

Hsiao, N. W., Tseng, T. S., Lee, Y. C., Chen, W. C., Lin, H. H., Chen, Y. R., Wang, Y. T., Hsu, H. J. & Tsai, K. C., 2014 Nov 24, In : Journal of Chemical Information and Modeling. 54, 11, p. 3099-3111 13 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Melanin
Monophenol Monooxygenase
Cosmetics
Biological Products
1 Citation (Scopus)

The S100A4 D10V polymorphism is related to cell migration ability but not drug resistance in gastric cancer cells

Yuan, T. M., Liang, R. Y., Hsiao, N. W. & Chuang, S. M., 2014 Dec 1, In : Oncology Reports. 32, 6, p. 2307-2318 12 p.

Research output: Contribution to journalArticle

Drug Resistance
Stomach Neoplasms
Cell Movement
Cell Survival
Pharmaceutical Preparations
2012
2 Citations (Scopus)

Characterization of glycine substitution mutations within the putative NAD+-binding site of bacillus licheniformis aldehyde dehydrogenase

Lee, Y. C., Lin, D. T., Chen, H. L., Lo, H. F., Hu, H. Y., Hsiao, N-W. & Lin, L. L., 2012 Nov 1, In : Protein and Peptide Letters. 19, 11, p. 1183-1193 11 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Bacilli
NAD
Glycine
Substitution reactions
3 Citations (Scopus)

Design of novel FLT-3 inhibitors based on dual-layer 3D-QSAR model and fragment-based compounds in silico

Shih, K. C., Lin, C. Y., Chi, H. C., Hwang, C. S., Chen, T. S., Tang, C. Y. & Hsiao, N. W., 2012 Jan 23, In : Journal of Chemical Information and Modeling. 52, 1, p. 146-155 10 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Values
costs
Costs
confidence
32 Citations (Scopus)

Fisetin and rutin as 3C protease inhibitors of enterovirus A71

Lin, Y. J., Chang, Y. C., Hsiao, N-W., Hsieh, J. L., Wang, C. Y., Kung, S. H., Tsai, F. J., Lan, Y. C. & Lin, C. W., 2012 Jun 1, In : Journal of Virological Methods. 182, 1-2, p. 93-98 6 p.

Research output: Contribution to journalArticle

Rutin
Enterovirus
Protease Inhibitors
Viral Cytopathogenic Effect
Fluorescence Resonance Energy Transfer
3 Citations (Scopus)

N-Acetyl-D-glucosamine 2-epimerase from Anabaena sp. CH1 contains a novel ATP-binding site required for catalytic activity

Liao, H. F., Kao, C. H., Lin, W. D., Hsiao, N. W., Hsu, W. H. & Lee, Y. C., 2012 Jun 1, In : Process Biochemistry. 47, 6, p. 948-952 5 p.

Research output: Contribution to journalArticle

Glucosamine
Anabaena
Adenosinetriphosphate
Binding sites
Catalyst activity
2011
3 Citations (Scopus)

Production of active nonglycosylated recombinant B-chain of type-2 ribosome-inactivating protein from viscum articulatum and its biological effects on peripheral blood mononuclear cells

Hsu, C. H., Lu, T. L., Chuang, J. Y., Yang, J. S., Chiu, S. T., Hsiao, N. W., Wu, M. C. & Wu, S. H., 2011 Jun 22, In : Evidence-based Complementary and Alternative Medicine. 2011, 283747.

Research output: Contribution to journalArticle

Type 2 Ribosome Inactivating Proteins
Viscum
Blood Cells
Protein Refolding
Galactosides
2010
34 Citations (Scopus)

A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies

Tsai, K. C., Chen, Y. C., Hsiao, N. W., Wang, C. L., Lin, C. L., Lee, Y. C., Li, M. & Wang, B., 2010 Apr 1, In : European Journal of Medicinal Chemistry. 45, 4, p. 1544-1551 8 p.

Research output: Contribution to journalArticle

Static Electricity
Electrostatics
Quantitative Structure-Activity Relationship
Computational chemistry
Atoms
37 Citations (Scopus)

ISG15 over-expression inhibits replication of the Japanese encephalitis virus in human medulloblastoma cells

Hsiao, N-W., Chen, J. W., Yang, T. C., Orloff, G. M., Wu, Y. Y., Lai, C. H., Lan, Y. C. & Lin, C. W., 2010 Mar 1, In : Antiviral Research. 85, 3, p. 504-511 8 p.

Research output: Contribution to journalArticle

Japanese Encephalitis Virus
Medulloblastoma
Genes
Chi-Square Distribution
Infection
21 Citations (Scopus)

Structural and functional comparisons and production of recombinant crustacean hyperglycemic hormone (CHH) and CHH-like peptides from the mud crab Scylla olivacea

Chang, C. C., Tsai, K. W., Hsiao, N. W., Chang, C. Y., Lin, C. L., Watson, R. D. & Lee, C. Y., 2010 May, In : General and Comparative Endocrinology. 167, 1, p. 68-76 9 p.

Research output: Contribution to journalArticle

Scylla olivacea
crabs
Crustacea
hormones
peptides
2009
30 Citations (Scopus)

Characterization, molecular modelling and developmental expression of zebrafish manganese superoxide dismutase

Lin, C. T., Tseng, W. C., Hsiao, N. W., Chang, H. H. & Ken, C. F., 2009 Aug, In : Fish and Shellfish Immunology. 27, 2, p. 318-324 7 p.

Research output: Contribution to journalArticle

paraquat
Molecular modeling
Danio rerio
Superoxide Dismutase
manganese
35 Citations (Scopus)

Predicting melting temperature directly from protein sequences

Ku, T., Lu, P., Chan, C., Wang, T., Lai, S., Lyu, P. & Hsiao, N-W., 2009 Dec 1, In : Computational Biology and Chemistry. 33, 6, p. 445-450 6 p.

Research output: Contribution to journalArticle

Protein Sequence
Melting
Freezing
Melting point
Proteins
5 Citations (Scopus)

The first pharmacophore model for potent NF-κB inhibitors

Tsai, K. C., Teng, L. W., Shao, Y. M., Chen, Y. C., Lee, Y. C., Li, M. & Hsiao, N. W., 2009 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 19, 19, p. 5665-5669 5 p.

Research output: Contribution to journalArticle

NF-kappa B
Molecules
Quantitative Structure-Activity Relationship
Bioactivity
Hydrogen
2008
68 Citations (Scopus)

Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71

Lin, C. W., Wu, C. F., Hsiao, N-W., Chang, C. Y., Li, S. W., Wan, L., Lin, Y. J. & Lin, W. Y., 2008 Oct 1, In : International Journal of Antimicrobial Agents. 32, 4, p. 355-359 5 p.

Research output: Contribution to journalArticle

Japanese Encephalitis Virus
Enterovirus
Interferons
Antiviral Agents
Inhibitory Concentration 50
25 Citations (Scopus)

The effect of different electrostatic potentials on docking accuracy: A case study using DOCK5.4

Tsai, K. C., Wang, S. H., Hsiao, N. W., Li, M. & Wang, B., 2008 Jun 15, In : Bioorganic and Medicinal Chemistry Letters. 18, 12, p. 3509-3512 4 p.

Research output: Contribution to journalArticle

Static Electricity
Crystal orientation
Conformations
Electrostatics
Screening
2007
11 Citations (Scopus)

Identification of a novel septin 4 protein binding to human herpesvirus 8 kaposin A protein using a phage display cDNA library

Lin, C. W., Tu, P. F., Hsiao, N-W., Chang, C. Y., Wan, L., Lin, Y. T. & Chang, H. W., 2007 Jul 1, In : Journal of Virological Methods. 143, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

Septins
Gene Library
Protein Binding
Bacteriophages
Human Herpesvirus 8
2005
6 Citations (Scopus)

Stabilization of a truncated Bacillus sp. strain TS-23 α-amylase by replacing histidine-436 with aspartate

Lo, H. F., Chen, Y. H., Hsiao, N-W., Chen, H. L., Hu, H. Y., Hsu, W. H. & Lin, L. L., 2005 Jun 1, In : World Journal of Microbiology and Biotechnology. 21, 4, p. 411-416 6 p.

Research output: Contribution to journalArticle

Bacilli
aspartic acid
Amylases
histidine
Histidine
2004
54 Citations (Scopus)

Relationship between local structural entropy and protein thermostability

Chan, C. H., Liang, H. K., Hsiao, N. W., Ko, M. T., Lyu, P. C. & Hwang, J. K., 2004 Dec 1, In : Proteins: Structure, Function and Genetics. 57, 4, p. 684-691 8 p.

Research output: Contribution to journalArticle

Entropy
Adenylate Kinase
Proteins
Stabilization
Hot Temperature
2003
7 Citations (Scopus)

Mutagenesis study on the zebra fish SOX9 high-mobility group: Comparison of sequence and non-sequence specific HMG domains

Hsiao, N-W., Samuel, D., Liu, Y. N., Chen, L. C., Yang, T. Y., Jayaraman, G. & Lyu, P. C., 2003 Sep 30, In : Biochemistry. 42, 38, p. 11183-11193 11 p.

Research output: Contribution to journalArticle

Mutagenesis
Zebrafish
Fish
DNA
High Mobility Group Proteins