Nai-Wan Hsiao

Associate Professor

  • 743 Citations
  • 13 h-Index
20032020

Research output per year

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Research Output

  • 743 Citations
  • 13 h-Index
  • 27 Article
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Article
2016

Comparative study between 3D-QSAR and Docking-Based Pharmacophore models for potent Plasomodium falciparum dihydroorotate dehydrogenase inhibitors

Tseng, T. S., Lee, Y. C., Hsiao, N. W., Liu, Y. R. & Tsai, K. C., 2016 Jan 15, In : Bioorganic and Medicinal Chemistry Letters. 26, 2, p. 265-271 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

Tseng, T. S., Chuang, S. M., Hsiao, N. W., Chen, Y. W., Lee, Y. C., Lin, C. C., Huang, C. & Tsai, K. C., 2016 Jan 1, In : Molecular BioSystems. 12, 8, p. 2541-2551 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2015

Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in vivo assay and computational molecular modeling

Chen, W. C., Tseng, T. S., Hsiao, N. W., Lin, Y. L., Wen, Z. H., Tsai, C. C., Lee, Y. C., Lin, H. H. & Tsai, K. C., 2015, In : Scientific Reports. 5, 7995.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation

Tseng, T. S., Tsai, K. C., Chen, W. C., Wang, Y. T., Lee, Y. C., Lu, C. K., Don, M. J., Chang, C. Y., Lee, C. H., Lin, H. H., Hsu, H. J. & Hsiao, N. W., 2015 Jul 15, In : Journal of Agricultural and Food Chemistry. 63, 27, p. 6181-6188 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Phage display - Mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom

Lee, Y. C., Hsiao, N. W., Tseng, T. S., Chen, W. C., Lin, H. H., Leu, S. J., Yang, E. W. & Tsai, K. C., 2015 Jan 1, In : Molecular Pharmacology. 87, 2, p. 218-230 13 p., A8.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2014

Antiviral treatment for hepatitis C virus infection is associated with improved renal and cardiovascular outcomes in diabetic patients

Hsu, Y. C., Lin, J. T., Ho, H. J., Kao, Y. H., Huang, Y. T., Hsiao, N. W., Wu, M. S., Liu, Y. Y. & Wu, C. Y., 2014 Apr, In : Hepatology. 59, 4, p. 1293-1302 10 p.

Research output: Contribution to journalArticle

179 Citations (Scopus)

Development of 3D-QSAR combination approach for discovering and analysing neuraminidase inhibitors in silico

Lin, C. Y., Chi, H. C., Shih, K. C., Zhou, J., Hsiao, N. W. & Tang, C. Y., 2014, In : International Journal of Data Mining and Bioinformatics. 9, 3, p. 305-320 16 p.

Research output: Contribution to journalArticle

Purification and characterization of an aspartic protease from the Rhizopus Oryzae protease extract, peptidase R

Hsiao, N. W., Chen, Y., Kuan, Y. C., Lee, Y. C., Lee, S. K., Chan, H. H. & Kao, C. H., 2014 Mar, In : Electronic Journal of Biotechnology. 17, 2, p. 89-94 6 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors

Hsiao, N. W., Tseng, T. S., Lee, Y. C., Chen, W. C., Lin, H. H., Chen, Y. R., Wang, Y. T., Hsu, H. J. & Tsai, K. C., 2014 Nov 24, In : Journal of Chemical Information and Modeling. 54, 11, p. 3099-3111 13 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

The S100A4 D10V polymorphism is related to cell migration ability but not drug resistance in gastric cancer cells

Yuan, T. M., Liang, R. Y., Hsiao, N. W. & Chuang, S. M., 2014 Dec 1, In : Oncology Reports. 32, 6, p. 2307-2318 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2012

Characterization of glycine substitution mutations within the putative NAD+-binding site of bacillus licheniformis aldehyde dehydrogenase

Lee, Y. C., Lin, D. T., Chen, H. L., Lo, H. F., Hu, H. Y., Hsiao, N-W. & Lin, L. L., 2012 Nov 1, In : Protein and Peptide Letters. 19, 11, p. 1183-1193 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Design of novel FLT-3 inhibitors based on dual-layer 3D-QSAR model and fragment-based compounds in silico

Shih, K. C., Lin, C. Y., Chi, H. C., Hwang, C. S., Chen, T. S., Tang, C. Y. & Hsiao, N. W., 2012 Jan 23, In : Journal of Chemical Information and Modeling. 52, 1, p. 146-155 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Fisetin and rutin as 3C protease inhibitors of enterovirus A71

Lin, Y. J., Chang, Y. C., Hsiao, N. W., Hsieh, J. L., Wang, C. Y., Kung, S. H., Tsai, F. J., Lan, Y. C. & Lin, C. W., 2012 Jun 1, In : Journal of Virological Methods. 182, 1-2, p. 93-98 6 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

N-Acetyl-D-glucosamine 2-epimerase from Anabaena sp. CH1 contains a novel ATP-binding site required for catalytic activity

Liao, H. F., Kao, C. H., Lin, W. D., Hsiao, N. W., Hsu, W. H. & Lee, Y. C., 2012 Jun 1, In : Process Biochemistry. 47, 6, p. 948-952 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2011
3 Citations (Scopus)
2010

A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies

Tsai, K. C., Chen, Y. C., Hsiao, N. W., Wang, C. L., Lin, C. L., Lee, Y. C., Li, M. & Wang, B., 2010 Apr 1, In : European Journal of Medicinal Chemistry. 45, 4, p. 1544-1551 8 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

ISG15 over-expression inhibits replication of the Japanese encephalitis virus in human medulloblastoma cells

Hsiao, N. W., Chen, J. W., Yang, T. C., Orloff, G. M., Wu, Y. Y., Lai, C. H., Lan, Y. C. & Lin, C. W., 2010 Mar 1, In : Antiviral Research. 85, 3, p. 504-511 8 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Structural and functional comparisons and production of recombinant crustacean hyperglycemic hormone (CHH) and CHH-like peptides from the mud crab Scylla olivacea

Chang, C. C., Tsai, K. W., Hsiao, N. W., Chang, C. Y., Lin, C. L., Watson, R. D. & Lee, C. Y., 2010 May, In : General and Comparative Endocrinology. 167, 1, p. 68-76 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2009

Characterization, molecular modelling and developmental expression of zebrafish manganese superoxide dismutase

Lin, C. T., Tseng, W. C., Hsiao, N. W., Chang, H. H. & Ken, C. F., 2009 Aug, In : Fish and Shellfish Immunology. 27, 2, p. 318-324 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Predicting melting temperature directly from protein sequences

Ku, T., Lu, P., Chan, C., Wang, T., Lai, S., Lyu, P. & Hsiao, N-W., 2009 Dec 1, In : Computational Biology and Chemistry. 33, 6, p. 445-450 6 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

The first pharmacophore model for potent NF-κB inhibitors

Tsai, K. C., Teng, L. W., Shao, Y. M., Chen, Y. C., Lee, Y. C., Li, M. & Hsiao, N. W., 2009 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 19, 19, p. 5665-5669 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2008

Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71

Lin, C. W., Wu, C. F., Hsiao, N. W., Chang, C. Y., Li, S. W., Wan, L., Lin, Y. J. & Lin, W. Y., 2008 Oct, In : International Journal of Antimicrobial Agents. 32, 4, p. 355-359 5 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

The effect of different electrostatic potentials on docking accuracy: A case study using DOCK5.4

Tsai, K. C., Wang, S. H., Hsiao, N. W., Li, M. & Wang, B., 2008 Jun 15, In : Bioorganic and Medicinal Chemistry Letters. 18, 12, p. 3509-3512 4 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2007

Identification of a novel septin 4 protein binding to human herpesvirus 8 kaposin A protein using a phage display cDNA library

Lin, C. W., Tu, P. F., Hsiao, N. W., Chang, C. Y., Wan, L., Lin, Y. T. & Chang, H. W., 2007 Jul 1, In : Journal of Virological Methods. 143, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2005

Stabilization of a truncated Bacillus sp. strain TS-23 α-amylase by replacing histidine-436 with aspartate

Lo, H. F., Chen, Y. H., Hsiao, N. W., Chen, H. L., Hu, H. Y., Hsu, W. H. & Lin, L. L., 2005 Jun 1, In : World Journal of Microbiology and Biotechnology. 21, 4, p. 411-416 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2004

Relationship between local structural entropy and protein thermostability

Chan, C. H., Liang, H. K., Hsiao, N. W., Ko, M. T., Lyu, P. C. & Hwang, J. K., 2004 Dec 1, In : Proteins: Structure, Function and Genetics. 57, 4, p. 684-691 8 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
2003

Mutagenesis study on the zebra fish SOX9 high-mobility group: Comparison of sequence and non-sequence specific HMG domains

Hsiao, N-W., Samuel, D., Liu, Y. N., Chen, L. C., Yang, T. Y., Jayaraman, G. & Lyu, P. C., 2003 Sep 30, In : Biochemistry. 42, 38, p. 11183-11193 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)