Ming-Hua Hsu

Assistant Professor

  • 1109 Citations
  • 14 h-Index
20022020

Research output per year

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Research Output

  • 1109 Citations
  • 14 h-Index
  • 41 Article
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Article
2020

Leucettamine B analogs and their carborane derivative as potential anti-cancer agents: Design, synthesis, and biological evaluation

Hsu, M. H., Hsieh, C. Y., Kapoor, M., Chang, J. H., Chu, H. L., Cheng, T. M., Hsu, K. C., Lin, T. E., Tsai, F. Y. & Horng, J. C., 2020 May, In : Bioorganic Chemistry. 98, 103729.

Research output: Contribution to journalArticle

Treatment with a New Barbituric Acid Derivative Exerts Antiproliferative and Antimigratory Effects against Sorafenib Resistance in Hepatocellular Carcinoma

Liao, Y. J., Hsu, S. M., Chien, C. Y., Wang, Y. H., Hsu, M. H. & Suk, F. M., 2020 Jun, In : Molecules. 25, 12, 285.

Research output: Contribution to journalArticle

Open Access
2019

Design and synthesis of benzimidazole-chalcone derivatives as potential anticancer agents

Hsieh, C. Y., Ko, P. W., Chang, Y. J., Kapoor, M., Liang, Y. C., Chu, H. L., Lin, H. H., Horng, J. C. & Hsu, M. H., 2019 Sep 6, In : Molecules. 24, 18, 3259.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Development of theranostic active-targeting boron-containing gold nanoparticles for boron neutron capture therapy (BNCT)

Wu, C. Y., Lin, J. J., Chang, W. Y., Hsieh, C. Y., Wu, C. C., Chen, H. S., Hsu, H. J., Yang, A. S., Hsu, M. H. & Kuo, W. Y., 2019 Nov 1, In : Colloids and Surfaces B: Biointerfaces. 183, 110387.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018

A paeonol derivative, YPH-PA3 promotes the differentiation of monocyte/macrophage lineage precursor cells into osteoblasts and enhances their autophagy

Tsai, C. H., Hsu, M. H., Huang, P. H., Hsieh, C. T., Chiu, Y. M., Shieh, D. C., Lee, Y. J., Tsay, G. J. & Wu, Y. Y., 2018 Aug 5, In : European Journal of Pharmacology. 832, p. 104-113 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Simultaneous detection of multiple pathogens by multiplex PCR coupled with DNA biochip hybridization

Tung, H. Y., Chen, W. C., Ou, B. R., Yeh, J. Y., Cheng, Y. H., Tsng, P. H., Hsu, M. H., Tsai, M. S. & Liang, Y. C., 2018 Apr 1, In : Laboratory Animals. 52, 2, p. 186-195 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Evaluation of LPS-induced acute lung injury attenuation in rats by aminothiazole-paeonol derivatives

Fu, P. K., Yang, C. Y., Huang, S. C., Hung, Y. W., Jeng, K. C., Huang, Y. P., Chuang, H., Huang, N. C., Li, J. P., Hsu, M. H. & Chen, J. K., 2017 Oct, In : Molecules. 22, 10, 1605.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Treatment with low-dose sorafenib in combination with a novel benzimidazole derivative bearing a pyrolidine side chain provides synergistic anti-proliferative effects against human liver cancer

Hsu, M. H., Hsu, S. M., Kuo, Y. C., Liu, C. Y., Hsieh, C. Y., Twu, Y. C., Wang, C. K., Wang, Y. H. & Liao, Y. J., 2017 Jan 1, In : RSC Advances. 7, 26, p. 16253-16263 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Advanced generation of paeonol-phenylsufonyl derivatives as potential anti-HBV agents

Huang, Y. P., Shih, H. P., Liang, Y. C., Lin, H. H., Lin, M. C., Chen, C. W., Huang, T. J., Kuo, Y. C., Han, C. C. & Hsu, M. H., 2016 Jan 1, In : RSC Advances. 6, 49, p. 43556-43562 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Design and synthesis of pyridine-pyrazole-sulfonate derivatives as potential anti-HBV agents

Chuang, H., Huang, L. C. S., Kapoor, M., Liao, Y. J., Yang, C. L., Chang, C. C., Wu, C. Y., Hwu, J. R., Huang, T. J. & Hsu, M. H., 2016 Jan 1, In : MedChemComm. 7, 5, p. 832-836 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Di-(2-ethylhexyl) phthalate accelerates atherosclerosis in apolipoprotein E-deficient mice

Zhao, J. F., Hsiao, S. H., Hsu, M. H., Pao, K. C., Kou, Y. R., Shyue, S. K. & Lee, T. S., 2016 Jan 1, In : Archives of Toxicology. 90, 1, p. 181-190 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

In vivo amelioration of endogenous antitumor autoantibodies via low-dose P4N through the LTA4H/activin A/BAFF pathway

Lin, Y. L., Tsai, N. M., Hsieh, C. H., Ho, S. Y., Chang, J., Wu, H. Y., Hsu, M. H., Chang, C. C., Liao, K. W., Jackson, T. L. B., Mold, D. E. & Huang, R. C. C., 2016 Nov 29, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 48, p. E7798-E7807

Research output: Contribution to journalArticle

3 Citations (Scopus)

Synthesis and evaluation of aminothiazole-paeonol derivatives as potential anticancer agents

Tsai, C. Y., Kapoor, M., Huang, Y. P., Lin, H. H., Liang, Y. C., Lin, Y. L., Huang, S. C., Liao, W. N., Chen, J. K., Huang, J. S. & Hsu, M. H., 2016 Feb, In : Molecules. 21, 2, 145.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Synthesis and structure-activity relationships of imidazole-coumarin conjugates against hepatitis C virus

Tsay, S. C., Lin, S. Y., Huang, W. C., Hsu, M. H., Hwang, K. C., Lin, C. C., Horng, J. C., Chen, I. C., Hwu, J. R., Shieh, F. K., Leyssen, P. & Neyts, J., 2016 Feb, In : Molecules. 21, 2, 228.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2015

Design, synthesis, and bioevaluation of paeonol derivatives as potential anti-HBV agents

Huang, T. J., Chuang, H., Liang, Y. C., Lin, H. H., Horng, J. C., Kuo, Y. C., Chen, C. W., Tsai, F. Y., Yen, S. C., Chou, S. C. & Hsu, M. H., 2015 Jan 27, In : European Journal of Medicinal Chemistry. 90, p. 428-435 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Development of nordihydroguaiaretic acid derivatives as potential multidrug-resistant selective agents for cancer treatment

Huang, L. C. S., Chuang, H., Kapoor, M., Hsieh, C. Y., Chou, S. C., Lin, H. H., Chen, Y. W., Chang, C. C., Hwu, J. R., Liang, Y. C. & Hsu, M. H., 2015 Dec 15, In : RSC Advances. 5, 130, p. 107833-107838 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Establishment of a trimodality analytical platform for tracing, imaging and quantification of gold nanoparticles in animals by radiotracer techniques

Chen, C. H., Lin, F. S., Liao, W. N., Liang, S. L., Chen, M. H., Chen, Y. W., Lin, W. Y., Hsu, M. H., Wang, M. Y., Peir, J. J., Chou, F. I., Chen, C. Y., Chen, S. Y., Huang, S. C., Yang, M. H., Hueng, D. Y., Hwu, Y., Yang, C. S. & Chen, J. K., 2015 Jan 6, In : Analytical Chemistry. 87, 1, p. 601-608 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Imparting Functionality to Biocatalysts via Embedding Enzymes into Nanoporous Materials by a de Novo Approach: Size-Selective Sheltering of Catalase in Metal-Organic Framework Microcrystals

Shieh, F. K., Wang, S. C., Yen, C. I., Wu, C. C., Dutta, S., Chou, L. Y., Morabito, J. V., Hu, P., Hsu, M. H., Wu, K. C. W. & Tsung, C. K., 2015 Apr 8, In : Journal of the American Chemical Society. 137, 13, p. 4276-4279 4 p.

Research output: Contribution to journalArticle

378 Citations (Scopus)

Low-dose paeonol derivatives alleviate lipid accumulation

Pao, K. C., Zhao, J. F., Lee, T. S., Huang, Y. P., Han, C. C., Sherlock Huang, L. C., Wu, K. H. & Hsu, M. H., 2015, In : RSC Advances. 5, 8, p. 5652-5656 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2014

Development of a growth-hormone-conjugated nanodiamond complex for cancer therapy

Chu, H. L., Chen, H. W., Tseng, S. H., Hsu, M. H., Ho, L. P., Chou, F. H., Li, M. P. H. Y., Chang, Y. C., Chen, P. H., Tsai, L. Y., Chou, C. C., Chen, J. S., Cheng, T. M. & Chang, C. C., 2014 May, In : ChemMedChem. 9, 5, p. 1023-1029 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Directly thiolated modification onto the surface of detonation nanodiamonds

Hsu, M. H., Chuang, H., Cheng, F. Y., Huang, Y. P., Han, C. C., Chen, J. Y., Huang, S. C., Chen, J. K., Wu, D. S., Chu, H. L. & Chang, C. C., 2014 May 28, In : ACS Applied Materials and Interfaces. 6, 10, p. 7198-7203 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Drug delivery system design and development for boron neutron capture therapy on cancer treatment

Sherlock Huang, L. C., Hsieh, W. Y., Chen, J. Y., Huang, S. C., Chen, J. K. & Hsu, M. H., 2014 Jun, In : Applied Radiation and Isotopes. 88, p. 89-93 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Hepatocellular carcinoma targeting agents: Conjugates of nitroimidazoles with trimethyl nordihydroguaiaretic acid

Hsu, M. H., Wu, S. C., Pao, K. C., Unlu, I., Gnabre, J. N., Mold, D. E., Huang, R. C. C. & Hwu, J. R., 2014 May, In : ChemMedChem. 9, 5, p. 1030-1037 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Identification of trans, trans-2,4-Decadienal metabolites in mouse and human cells using liquid chromatography-mass spectrometry

Pan, K. L., Huang, W. J., Hsu, M. H., Lee, H. L., Liu, H. J., Cheng, C. W., Tsai, M. H., Shen, M. Y. & Lin, P., 2014 Oct 20, In : Chemical Research in Toxicology. 27, 10, p. 1707-1719 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Microwave assistance of labeling hippuric acid by I-131

Sherlock Huang, L. C., Wu, K. H., Ko, P. W., Hsieh, C. Y., Pao, K. C., Chou, S. C., Shieh, F. K., Sureshbabu, R. & Hsu, M-H., 2014 Jul 1, In : Applied Radiation and Isotopes. 89, p. 53-57 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Simple and highly efficient direct thiolation of the surface of carbon nanotubes

Hsu, M. H., Chuang, H., Cheng, F. Y., Huang, Y. P., Han, C. C., Pao, K. C., Chou, S. C., Shieh, F. K., Tsai, F. Y., Lin, C. C., Wu, D. S. & Chang, C. C., 2014, In : RSC Advances. 4, 28, p. 14777-14780 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2013

A bioconjugated design for amino acid-modified mesoporous silicas as effective adsorbents for toxic chemicals

Shieh, F. K., Hsiao, C. T., Wu, J. W., Sue, Y. C., Bao, Y. L., Liu, Y. H., Wan, L., Hsu, M. H., Deka, J. R. & Kao, H. M., 2013 Sep 15, In : Journal of Hazardous Materials. 260, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus

Tsay, S. C., Hwu, J. R., Singha, R., Huang, W. C., Chang, Y. H., Hsu, M. H., Shieh, F. K., Lin, C. C., Hwang, K. C., Horng, J. C., De Clercq, E., Vliegen, I. & Neyts, J., 2013 Mar 18, In : European Journal of Medicinal Chemistry. 63, p. 290-298 9 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Relationship between structure of conjugated oxime esters and their ability to cleave DNA

Hwu, J. R., Tsay, S. C., Hong, S. C., Hsu, M. H., Liu, C. F. & Chou, S. S. P., 2013 Nov 20, In : Bioconjugate Chemistry. 24, 11, p. 1778-1783 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Size-adjustable annular ring-functionalized mesoporous silica as effective and selective adsorbents for heavy metal ions

Shieh, F. K., Hsiao, C. T., Kao, H. M., Sue, Y. C., Lin, K. W., Wu, C. C., Chen, X. H., Wan, L., Hsu, M. H., Hwu, J. R., Tsung, C. K. & Wu, K. C. W., 2013 Dec 28, In : RSC Advances. 3, 48, p. 25686-25689 4 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Synthesis of apolipoprotein B lipoparticles to deliver hydrophobic/ amphiphilic materials

Chu, H. L., Cheng, T. M., Chen, H. W., Chou, F. H., Chang, Y. C., Lin, H. Y., Liu, S. Y., Liang, Y. C., Hsu, M. H., Wu, D. S., Li, H. Y., Ho, L. P., Wu, P. C., Chen, F. R., Chen, G. S., Shieh, D. B., Chang, C. S., Su, C. H., Yao, Z. & Chang, C. C., 2013 Aug 14, In : ACS Applied Materials and Interfaces. 5, 15, p. 7509-7516 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2011

Glycosylated nordihydroguaiaretic acids as anti-cancer agents

Hwu, J. R., Hsu, C. I., Hsu, M. H., Liang, Y. C., Huang, R. C. C. & Lee, Y. C., 2011 Jan 1, In : Bioorganic and Medicinal Chemistry Letters. 21, 1, p. 380-382 3 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2009

Photochemical activities of n-nitroso carboxamides and sulfoximides and their application to DNA cleavage

Hwu, J. R., Huang, J. J. T., Tsai, F. Y., Tsay, S. C., Hsu, M. H., Hwang, K. C., Horng, J. C., Ho, J. A. A. & Lin, C. C., 2009 Sep 7, In : Chemistry - A European Journal. 15, 35, p. 8742-8750 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Structure-activity relationship of new anti-hepatitis C virus agents: Heterobicycle-coumarin conjugates

Neyts, J., De Clercq, E., Singha, R., Chang, Y. H., Das, A. R., Chakraborty, S. K., Hong, S. C., Tsay, S. C., Hsu, M. H. & Hwu, J. R., 2009 Mar 12, In : Journal of Medicinal Chemistry. 52, 5, p. 1486-1490 5 p.

Research output: Contribution to journalArticle

148 Citations (Scopus)

Targeted paclitaxel by conjugation to iron oxide and gold nanoparticles

Hwu, J. R., Lin, Y. S., Josephrajan, T., Hsu, M. H., Cheng, F. Y., Yeh, C. S., Su, W. C. & Shieh, D. B., 2009 Jan 14, In : Journal of the American Chemical Society. 131, 1, p. 66-68 3 p.

Research output: Contribution to journalArticle

141 Citations (Scopus)
2008

New nordihydroguaiaretic acid derivatives as anti-HIV agents

Hwu, J. R., Hsu, M. H. & Huang, R. C. C., 2008 Mar 15, In : Bioorganic and Medicinal Chemistry Letters. 18, 6, p. 1884-1888 5 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Photo-induced DNA cleavage by (heterocyclo)carbonyl oxime esters of anthraquinone

Hwu, J. R., Yang, J. R., Tsay, S. C., Hsu, M. H., Chen, Y. C. & Chou, S. S. P., 2008 May 12, In : Tetrahedron Letters. 49, 20, p. 3312-3315 4 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2007

Novel arylhydrazone-conjugated gold nanoparticles with DNA-cleaving ability: The first DNA-nicking nanomaterial

Hsu, M. H., Josephrajan, T., Yeh, C. S., Shieh, D. B., Su, W. C. & Jih, R. H., 2007 Nov 1, In : Bioconjugate Chemistry. 18, 6, p. 1709-1712 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2005

1,2-Eliminations in a novel reductive coupling of nitroarenes to give azoxy arenes by sodium bis(trimethylsilyl)amide

Jih, R. H., Das, A. R., Chia, W. Y., Huang, J. J. & Hsu, M. H., 2005 Jul 21, In : Organic Letters. 7, 15, p. 3211-3214 4 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Influence of ions, hydration, and the transcriptional inhibitor P4N on the conformations of the Sp1 binding site

Dohm, J. A., Hsu, M. H., Hwu, J. R., Huang, R. C. C., Moudrianakis, E. N., Lattman, E. E. & Gittis, A. G., 2005 Jun 17, In : Journal of Molecular Biology. 349, 4, p. 731-744 14 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2002

A novel approach towards studying non-genotoxic enediynes as potential anticancer therapeutics

Hakimelahi, G. H., Gassanov, G. S., Hsu, M. H., Hwu, J. R. & Hakimelahi, S., 2002 Mar 21, In : Bioorganic and Medicinal Chemistry. 10, 5, p. 1321-1328 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)